6hkq
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Human GPX4 in complex with covalent Inhibitor ML162 (S enantiomer)== | |
| - | + | <StructureSection load='6hkq' size='340' side='right'caption='[[6hkq]], [[Resolution|resolution]] 1.54Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6hkq]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6HKQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6HKQ FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=G9N:(2~{S})-2-[2-chloranylethanoyl-(3-chloranyl-4-methoxy-phenyl)amino]-~{N}-(2-phenylethyl)-2-thiophen-2-yl-ethanamide'>G9N</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |
| - | [[Category: | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[6hn3|6hn3]]</td></tr> |
| + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phospholipid-hydroperoxide_glutathione_peroxidase Phospholipid-hydroperoxide glutathione peroxidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.11.1.12 1.11.1.12] </span></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6hkq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6hkq OCA], [http://pdbe.org/6hkq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6hkq RCSB], [http://www.ebi.ac.uk/pdbsum/6hkq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6hkq ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/GPX4_HUMAN GPX4_HUMAN]] Protects cells against membrane lipid peroxidation and cell death. Required for normal sperm development and male fertility. Could play a major role in protecting mammals from the toxicity of ingested lipid hydroperoxides. Essential for embryonic development. Protects from radiation and oxidative damage (By similarity). | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Phospholipid-hydroperoxide glutathione peroxidase]] | ||
| + | [[Category: Badock, V]] | ||
| + | [[Category: Eaton, J K]] | ||
| + | [[Category: Gradl, S]] | ||
| + | [[Category: Hillig, R C]] | ||
| + | [[Category: Hilpmann, A]] | ||
| + | [[Category: Hoffmann, L]] | ||
| + | [[Category: Moosmayer, D]] | ||
| + | [[Category: Schnirch, L]] | ||
| + | [[Category: Anti-oxidatve defense system]] | ||
| + | [[Category: Covalent inhibitor]] | ||
| + | [[Category: Oxidoreductase]] | ||
Revision as of 09:04, 1 April 2020
Human GPX4 in complex with covalent Inhibitor ML162 (S enantiomer)
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