6oda

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'''Unreleased structure'''
 
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The entry 6oda is ON HOLD until Paper Publication
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==Crystal structure of HDAC8 in complex with compound 2==
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<StructureSection load='6oda' size='340' side='right'caption='[[6oda]], [[Resolution|resolution]] 2.88&Aring;' scene=''>
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Authors: Zheng, X., Conti, C., Caravella, J., Zablocki, M.-M., Bair, K., Barczak, N., Han, B., Lancia Jr., D., Liu, C., Martin, M., Ng, P.Y., Rudnitskaya, A., Thomason, J.J., Garcia-Dancey, R., Hardy, C., Lahdenranta, J., Leng, C., Li, P., Pardo, E., Saldahna, A., Tan, T., Toms, A.V., Yao, L., Zhang, C.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[6oda]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ODA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ODA FirstGlance]. <br>
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Description: Crystal structure of HDAC8 in complex with compound 2
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=C7:2-(4-CHLOROPHENYL)-4-[(3S)-PIPERIDIN-3-YLAMINO]THIENO[2,3-D]PYRIDAZINE-7-CARBOXAMIDE'>C7</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Histone_deacetylase Histone deacetylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.1.98 3.5.1.98] </span></td></tr>
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[[Category: Tan, T]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6oda FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6oda OCA], [http://pdbe.org/6oda PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6oda RCSB], [http://www.ebi.ac.uk/pdbsum/6oda PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6oda ProSAT]</span></td></tr>
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[[Category: Rudnitskaya, A]]
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</table>
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[[Category: Leng, C]]
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== Function ==
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[[http://www.uniprot.org/uniprot/HDAC8_HUMAN HDAC8_HUMAN]] Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. May play a role in smooth muscle cell contractility.<ref>PMID:10748112</ref> <ref>PMID:10926844</ref> <ref>PMID:10922473</ref> <ref>PMID:14701748</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Histone deacetylase]]
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[[Category: Large Structures]]
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[[Category: Bair, K]]
[[Category: Barczak, N]]
[[Category: Barczak, N]]
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[[Category: Lancia Jr]]
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[[Category: Caravella, J]]
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[[Category: Conti, C]]
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[[Category: Garcia-Dancey, R]]
[[Category: Han, B]]
[[Category: Han, B]]
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[[Category: Zablocki, M.-M]]
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[[Category: Hardy, C]]
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[[Category: Yao, L]]
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[[Category: Lahdenranta, J]]
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[[Category: Lancia, D]]
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[[Category: Leng, C]]
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[[Category: Li, P]]
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[[Category: Liu, C]]
[[Category: Martin, M]]
[[Category: Martin, M]]
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[[Category: Bair, K]]
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[[Category: Ng, P Y]]
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[[Category: Toms, A.V]]
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[[Category: Pardo, E]]
[[Category: Pardo, E]]
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[[Category: Zheng, X]]
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[[Category: Rudnitskaya, A]]
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[[Category: Conti, C]]
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[[Category: Liu, C]]
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[[Category: Hardy, C]]
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[[Category: Caravella, J]]
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[[Category: Lahdenranta, J]]
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[[Category: Saldahna, A]]
[[Category: Saldahna, A]]
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[[Category: Garcia-Dancey, R]]
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[[Category: Tan, T]]
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[[Category: Thomason, J J]]
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[[Category: Toms, A V]]
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[[Category: Yao, L]]
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[[Category: Zablocki, M M]]
[[Category: Zhang, C]]
[[Category: Zhang, C]]
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[[Category: D]]
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[[Category: Zheng, X]]
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[[Category: Li, P]]
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[[Category: Hdac8]]
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[[Category: Ng, P.Y]]
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[[Category: Hydrolase]]
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[[Category: Thomason, J.J]]
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[[Category: Hydroxamic acid]]

Revision as of 09:12, 1 April 2020

Crystal structure of HDAC8 in complex with compound 2

PDB ID 6oda

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