6r7g
From Proteopedia
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6r7g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6r7g OCA], [http://pdbe.org/6r7g PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6r7g RCSB], [http://www.ebi.ac.uk/pdbsum/6r7g PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6r7g ProSAT]</span></td></tr> | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6r7g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6r7g OCA], [http://pdbe.org/6r7g PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6r7g RCSB], [http://www.ebi.ac.uk/pdbsum/6r7g PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6r7g ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Potato virus X (PVX) is a positive-sense single-stranded RNA (ssRNA) filamentous plant virus belonging to the Alphaflexiviridae family, considered in recent years as a tool for nanotechnology applications. We present the cryo-electron microscopy structure of the PVX particle at a resolution of 2.2 A. The well-defined density of the coat proteins and of the genomic RNA allowed a detailed analysis of protein-RNA interactions, including those mediated by solvent molecules. The particle is formed by repeated segments made of 8.8 coat proteins, forming a left-handed helical structure. The RNA runs in an internal crevice along the virion, packaged in 5-nucleotide repeats in which the first four bases are stacked in the classical way, while the fifth is rotated and nearly perpendicular. The resolution of the structure described here suggests a mechanism for the virion assembly and potentially provides a platform for the rational design of antiviral compounds and for the use of PVX in nanotechnology. | ||
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| + | Atomic structure of potato virus X, the prototype of the Alphaflexiviridae family.,Grinzato A, Kandiah E, Lico C, Betti C, Baschieri S, Zanotti G Nat Chem Biol. 2020 Mar 16. pii: 10.1038/s41589-020-0502-4. doi:, 10.1038/s41589-020-0502-4. PMID:32203412<ref>PMID:32203412</ref> | ||
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| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 6r7g" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
Revision as of 09:39, 1 April 2020
Atomic structure of potato virus X, the prototype of the Alphaflexiviridae family
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Categories: Large Structures | Potato virus x | Baschieri, S | Betti, C | Grinzato, A | Kandiah, E | Lico, C | Zanotti, G | Coat protein | Rna | Virus
