1awi

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[[Image:1awi.gif|left|200px]]
[[Image:1awi.gif|left|200px]]
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{{Structure
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|PDB= 1awi |SIZE=350|CAPTION= <scene name='initialview01'>1awi</scene>, resolution 2.2&Aring;
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|SITE= <scene name='pdbsite=PPA:Poly-L-PRO+Binding+Site'>PPA</scene> and <scene name='pdbsite=PPB:Poly-L-PRO+Binding+Site'>PPB</scene>
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{{STRUCTURE_1awi| PDB=1awi | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1awi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1awi OCA], [http://www.ebi.ac.uk/pdbsum/1awi PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1awi RCSB]</span>
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'''HUMAN PLATELET PROFILIN COMPLEXED WITH THE L-PRO10 PEPTIDE'''
'''HUMAN PLATELET PROFILIN COMPLEXED WITH THE L-PRO10 PEPTIDE'''
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[[Category: Almo, S C.]]
[[Category: Almo, S C.]]
[[Category: Mahoney, N M.]]
[[Category: Mahoney, N M.]]
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[[Category: actin cytoskeleton]]
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[[Category: Actin cytoskeleton]]
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[[Category: complex (actin-binding protein/peptide)]]
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[[Category: Poly-l-proline]]
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[[Category: poly-l-proline]]
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[[Category: Profilin]]
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[[Category: profilin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 10:46:50 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 18:48:52 2008''
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Revision as of 07:46, 2 May 2008

Image:1awi.gif

Template:STRUCTURE 1awi

HUMAN PLATELET PROFILIN COMPLEXED WITH THE L-PRO10 PEPTIDE


Overview

Profilin, a ubiquitous low molecular weight (13,000-15,000 M(r)) actin binding protein, regulates the formation of F-actin structures in vivo, and is localized to specific cellular regions through interaction with proline-rich sequences. Here we report the 2.2 A X-ray structure of the complex between human platelet profilin (HPP) and a decamer of L-proline (L-Pro10). The L-Pro10 peptide adopts a left-handed type II poly-L-proline helix (PPII) and binds to a highly conserved patch of aromatic amino acids on the surface of profilin. The peptide and actin binding sites reside on orthogonal surfaces, and L-Pro10 binding does not result in a conformational rearrangement of HPP. This structure suggests a mechanism for the localization of profilin and its actin-related activities to sites of actin filament assembly in vivo.

About this Structure

1AWI is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure of the profilin-poly-L-proline complex involved in morphogenesis and cytoskeletal regulation., Mahoney NM, Janmey PA, Almo SC, Nat Struct Biol. 1997 Nov;4(11):953-60. PMID:9360613 Page seeded by OCA on Fri May 2 10:46:50 2008

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OCA

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