This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1awi

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
[[Image:1awi.gif|left|200px]]
[[Image:1awi.gif|left|200px]]
-
{{Structure
+
<!--
-
|PDB= 1awi |SIZE=350|CAPTION= <scene name='initialview01'>1awi</scene>, resolution 2.2&Aring;
+
The line below this paragraph, containing "STRUCTURE_1awi", creates the "Structure Box" on the page.
-
|SITE= <scene name='pdbsite=PPA:Poly-L-PRO+Binding+Site'>PPA</scene> and <scene name='pdbsite=PPB:Poly-L-PRO+Binding+Site'>PPB</scene>
+
You may change the PDB parameter (which sets the PDB file loaded into the applet)
-
|LIGAND=
+
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-
|ACTIVITY=
+
or leave the SCENE parameter empty for the default display.
-
|GENE=
+
-->
-
|DOMAIN=
+
{{STRUCTURE_1awi| PDB=1awi | SCENE= }}
-
|RELATEDENTRY=
+
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1awi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1awi OCA], [http://www.ebi.ac.uk/pdbsum/1awi PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1awi RCSB]</span>
+
-
}}
+
'''HUMAN PLATELET PROFILIN COMPLEXED WITH THE L-PRO10 PEPTIDE'''
'''HUMAN PLATELET PROFILIN COMPLEXED WITH THE L-PRO10 PEPTIDE'''
Line 27: Line 24:
[[Category: Almo, S C.]]
[[Category: Almo, S C.]]
[[Category: Mahoney, N M.]]
[[Category: Mahoney, N M.]]
-
[[Category: actin cytoskeleton]]
+
[[Category: Actin cytoskeleton]]
-
[[Category: complex (actin-binding protein/peptide)]]
+
[[Category: Poly-l-proline]]
-
[[Category: poly-l-proline]]
+
[[Category: Profilin]]
-
[[Category: profilin]]
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 10:46:50 2008''
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 18:48:52 2008''
+

Revision as of 07:46, 2 May 2008

Image:1awi.gif

Template:STRUCTURE 1awi

HUMAN PLATELET PROFILIN COMPLEXED WITH THE L-PRO10 PEPTIDE


Overview

Profilin, a ubiquitous low molecular weight (13,000-15,000 M(r)) actin binding protein, regulates the formation of F-actin structures in vivo, and is localized to specific cellular regions through interaction with proline-rich sequences. Here we report the 2.2 A X-ray structure of the complex between human platelet profilin (HPP) and a decamer of L-proline (L-Pro10). The L-Pro10 peptide adopts a left-handed type II poly-L-proline helix (PPII) and binds to a highly conserved patch of aromatic amino acids on the surface of profilin. The peptide and actin binding sites reside on orthogonal surfaces, and L-Pro10 binding does not result in a conformational rearrangement of HPP. This structure suggests a mechanism for the localization of profilin and its actin-related activities to sites of actin filament assembly in vivo.

About this Structure

1AWI is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure of the profilin-poly-L-proline complex involved in morphogenesis and cytoskeletal regulation., Mahoney NM, Janmey PA, Almo SC, Nat Struct Biol. 1997 Nov;4(11):953-60. PMID:9360613 Page seeded by OCA on Fri May 2 10:46:50 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1awi"
Personal tools