5d8e
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
==crystal structure of SSB from homo sapiens== | ==crystal structure of SSB from homo sapiens== | ||
| - | <StructureSection load='5d8e' size='340' side='right' caption='[[5d8e]], [[Resolution|resolution]] 3.00Å' scene=''> | + | <StructureSection load='5d8e' size='340' side='right'caption='[[5d8e]], [[Resolution|resolution]] 3.00Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[5d8e]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5D8E OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5D8E FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[5d8e]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5D8E OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5D8E FirstGlance]. <br> |
</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr> | </td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr> | ||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5d8f|5d8f]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5d8f|5d8f]]</td></tr> | ||
| + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">NABP2, OBFC2B, SSB1, LP3587 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5d8e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5d8e OCA], [http://pdbe.org/5d8e PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5d8e RCSB], [http://www.ebi.ac.uk/pdbsum/5d8e PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5d8e ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5d8e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5d8e OCA], [http://pdbe.org/5d8e PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5d8e RCSB], [http://www.ebi.ac.uk/pdbsum/5d8e PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5d8e ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[[http://www.uniprot.org/uniprot/SOSB1_HUMAN SOSB1_HUMAN]] Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. In the SOSS complex, acts as a sensor of single-stranded DNA that binds to single-stranded DNA, in particular to polypyrimidines. The SOSS complex associates with DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways.<ref>PMID:18449195</ref> <ref>PMID:19605351</ref> <ref>PMID:19683501</ref> | [[http://www.uniprot.org/uniprot/SOSB1_HUMAN SOSB1_HUMAN]] Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. In the SOSS complex, acts as a sensor of single-stranded DNA that binds to single-stranded DNA, in particular to polypyrimidines. The SOSS complex associates with DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways.<ref>PMID:18449195</ref> <ref>PMID:19605351</ref> <ref>PMID:19683501</ref> | ||
| + | |||
| + | ==See Also== | ||
| + | *[[Single-stranded DNA-binding protein 3D structures|Single-stranded DNA-binding protein 3D structures]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Human]] | ||
| + | [[Category: Large Structures]] | ||
[[Category: Dong, Y H]] | [[Category: Dong, Y H]] | ||
[[Category: Gao, Z Q]] | [[Category: Gao, Z Q]] | ||
Revision as of 10:42, 1 April 2020
crystal structure of SSB from homo sapiens
| |||||||||||
