Condensin

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==Your Heading Here (maybe something like 'Structure')==
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<StructureSection load='1stp' size='340' side='right' caption='Caption for this structure' scene=''>
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This is a default text for your page '''Condensin'''. Click above on '''edit this page''' to modify. Be careful with the &lt; and &gt; signs.
 
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You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue.
 
== Function ==
== Function ==
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'''Condensin''' or '''structural maintenance of chromosome protein''' (SMC) is required for correctly package and divide the cell's genome. SMC uses ATP to affect conformational changes in DNA, to correct DNA compaction, organization and segregation<ref>PMID:28181049</ref>. SMC exhibits the ability to super-coil DNA<ref>PMID:23218009</ref>.
== Disease ==
== Disease ==
== Relevance ==
== Relevance ==
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SMC plays important role in human disease and bacterial pathogenicity and its inhibitors are studied for therapeutic purposes<ref>PMID:30346684</ref>.
== Structural highlights ==
== Structural highlights ==
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This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.
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SMC is a multisubunit complex.
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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*Condensin or Structural Maintenance of Chromosome Protein
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*Condensin or Structural Maintenance of Chromosome Protein; Domains - head 1-219+983-1186
[[4u4p]] – hSMC2 hinge domain 506-666 + SMC4 hinge domain 595-752 – human <br />
[[4u4p]] – hSMC2 hinge domain 506-666 + SMC4 hinge domain 595-752 – human <br />
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[[6qj0]], [[6qj1]] – CtSMC head domain <br />
[[6qj0]], [[6qj1]] – CtSMC head domain <br />
[[6qj2]] – CtSMC head domain + Brn1<br />
[[6qj2]] – CtSMC head domain + Brn1<br />
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[[3zgx]] – BsSMC head domain residues 1-219, 983-1186 + segregation and condensation protein – ''Bacillus subtilis''<br />
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[[3zgx]] – BsSMC head domain + segregation and condensation protein – ''Bacillus subtilis''<br />
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[[5xg3]] – BsSMC head domain residues 1-219, 983-1186 (mutant)+ coiled-coil domain + segregation and condensation protein <br />
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[[5xg3]] – BsSMC head domain (mutant)+ coiled-coil domain + segregation and condensation protein <br />
[[1xew]] – PfSMC head domain – ''Pyrococcus furiosus''<br />
[[1xew]] – PfSMC head domain – ''Pyrococcus furiosus''<br />
[[1xex]] – PfSMC head domain (mutant)<br />
[[1xex]] – PfSMC head domain (mutant)<br />
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[[5xei]] – PySMC head+coiled-coil domains – <br />
[[5xei]] – PySMC head+coiled-coil domains – <br />
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*Structural Maintenance of Chromosome-related Protein or Chromosome partition protein
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**[[2wmm]] – EcMukB hinge domain 645-804 (mutant) - ''Escherichia coli'' <br />
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**[[4mn4]] – EcMukB hinge domain 645-804 * DNA topoisomerase 4 subunit A <br />
== References ==
== References ==

Revision as of 13:26, 2 April 2020

Caption for this structure

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3D Structures of condensin

Updated on 02-April-2020

  • Condensin or Structural Maintenance of Chromosome Protein; Domains - head 1-219+983-1186

4u4p – hSMC2 hinge domain 506-666 + SMC4 hinge domain 595-752 – human
6igx – hSMC subunit 2+3
3l51 – SMC2 hinge domain 506-666 + SMC4 hinge domain 595-752 – mouse
5oqq – ySMC subunit 2+3 – yeast
5oqn, 5oqo, 5oqp – ySMC subunit 2+3 + DNA
5oqr – SMC subunit 2+3 – fission yeast
6q6e – CtSMC residues 112-209 – Chaetomium thermophilum - NMR
6qj3 – CtSMC subunit 1+2 + Brn1
6qj4 – CtSMC subunit 1+2 + Brn1 + protein
6qj0, 6qj1 – CtSMC head domain
6qj2 – CtSMC head domain + Brn1
3zgx – BsSMC head domain + segregation and condensation protein – Bacillus subtilis
5xg3 – BsSMC head domain (mutant)+ coiled-coil domain + segregation and condensation protein
1xew – PfSMC head domain – Pyrococcus furiosus
1xex – PfSMC head domain (mutant)
4i99 – PfSMC head domain residues 1-182, 1006-1176 + protein
5xns – PfSMC head domain residues 1-219, 983-1186 + segregation and condensation protein
5xg2 – PySMC coiled-coil domain – Pyrococcus yayanosii
5xei – PySMC head+coiled-coil domains –

  • Structural Maintenance of Chromosome-related Protein or Chromosome partition protein
    • 2wmm – EcMukB hinge domain 645-804 (mutant) - Escherichia coli
    • 4mn4 – EcMukB hinge domain 645-804 * DNA topoisomerase 4 subunit A

References

  1. ↑ Kalitsis P, Zhang T, Marshall KM, Nielsen CF, Hudson DF. Condensin, master organizer of the genome. Chromosome Res. 2017 Mar;25(1):61-76. doi: 10.1007/s10577-017-9553-0. Epub 2017, Feb 9. PMID:28181049 doi:http://dx.doi.org/10.1007/s10577-017-9553-0
  2. ↑ Thadani R, Uhlmann F, Heeger S. Condensin, chromatin crossbarring and chromosome condensation. Curr Biol. 2012 Dec 4;22(23):R1012-21. doi: 10.1016/j.cub.2012.10.023. PMID:23218009 doi:http://dx.doi.org/10.1016/j.cub.2012.10.023
  3. ↑ Zhao H, Petrushenko ZM, Walker JK, Baudry J, Zgurskaya HI, Rybenkov VV. Small Molecule Condensin Inhibitors. ACS Infect Dis. 2018 Dec 14;4(12):1737-1745. doi: 10.1021/acsinfecdis.8b00222., Epub 2018 Oct 22. PMID:30346684 doi:http://dx.doi.org/10.1021/acsinfecdis.8b00222

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel

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