Sandbox Reserved 1606

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 19: Line 19:
===Cavities and Leucine Plug===
===Cavities and Leucine Plug===
[[Image:Map_leucine_plug.png|200 px|left|thumb|Figure 2. Locations of Cavities 1 and 2 and the Leucine Plug in ABCG2.]]
[[Image:Map_leucine_plug.png|200 px|left|thumb|Figure 2. Locations of Cavities 1 and 2 and the Leucine Plug in ABCG2.]]
-
 
+
Cavity 1 acts as the multidrug binding pocket
-
<scene name='83/832932/Lysine_plug_use/1'>Leucine Plug</scene>
+
<scene name='83/832932/Cavity_1_-_use2/1'>Cavity 1 (close up)</scene>
<scene name='83/832932/Cavity_1_-_use2/1'>Cavity 1 (close up)</scene>
<scene name='83/832932/Cavity_1_zoom_out/1'>Cavity 1 (zoom out)</scene>
<scene name='83/832932/Cavity_1_zoom_out/1'>Cavity 1 (zoom out)</scene>
 +
 +
<scene name='83/832932/Lysine_plug_use/1'>Leucine Plug</scene>
 +
==Disease==
==Disease==

Revision as of 20:26, 4 April 2020

This Sandbox is Reserved from Jan 13 through September 1, 2020 for use in the course CH462 Biochemistry II taught by R. Jeremy Johnson at the Butler University, Indianapolis, USA. This reservation includes Sandbox Reserved 1598 through Sandbox Reserved 1627.
To get started:
  • Click the edit this page tab at the top. Save the page after each step, then edit it again.
  • show the Scene authoring tools, create a molecular scene, and save it. Copy the green link into the page.
  • Add a description of your scene. Use the buttons above the wikitext box for bold, italics, links, headlines, etc.

More help: Help:Editing

ABCG2 Multidrug Transporter

ABCG2 Multidrug Transporter

Drag the structure with the mouse to rotate

References

[1] [2]

  1. ↑ 1.0 1.1 1.2 1.3 Taylor NMI, Manolaridis I, Jackson SM, Kowal J, Stahlberg H, Locher KP. Structure of the human multidrug transporter ABCG2. Nature. 2017 Jun 22;546(7659):504-509. doi: 10.1038/nature22345. Epub 2017 May, 29. PMID:28554189 doi:http://dx.doi.org/10.1038/nature22345
  2. ↑ 2.0 2.1 Manolaridis I, Jackson SM, Taylor NMI, Kowal J, Stahlberg H, Locher KP. Cryo-EM structures of a human ABCG2 mutant trapped in ATP-bound and substrate-bound states. Nature. 2018 Nov;563(7731):426-430. doi: 10.1038/s41586-018-0680-3. Epub 2018 Nov, 7. PMID:30405239 doi:http://dx.doi.org/10.1038/s41586-018-0680-3

Student Contributors

Julia Pomeroy

Retrieved from "http://52.214.119.220/wiki/index.php/Sandbox_Reserved_1606"
Personal tools