Furin
From Proteopedia
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(New page: <StructureSection load='1stp' size='340' side='right' caption='Caption for this structure' scene=''> == Function '''Furin''' or '''proprotein convertase furin''' or '''dibasic-processi...) |
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'''Furin''' or '''proprotein convertase furin''' or '''dibasic-processing enzyme''' or '''paired basic amino acid residue-cleaving enzyme''' or '''PACE''' is a member of the proprotein convertase family and promotes the proteoplytic maturation of proproteins. Furin cleaves precursor proteins at their paired basic amino acid processing sites<ref>PMID:12360192</ref>. | '''Furin''' or '''proprotein convertase furin''' or '''dibasic-processing enzyme''' or '''paired basic amino acid residue-cleaving enzyme''' or '''PACE''' is a member of the proprotein convertase family and promotes the proteoplytic maturation of proproteins. Furin cleaves precursor proteins at their paired basic amino acid processing sites<ref>PMID:12360192</ref>. | ||
Revision as of 08:18, 6 April 2020
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3D structures of furin
Updated on 06-April-2020
5jxg, 5jxi - hFur - human
6eqx, 6eqw, 6eqv, 5jxh, 5jxj, 6hlb, 6hld, 6hle, 6hza, 6hzb, 6hzc, 6hzd - hFur + peptide inhibitor
5mim - hFur + inhibitor
1p8j - mFur + peptide inhibitor - mouse
References
- ↑ Thomas G. Furin at the cutting edge: from protein traffic to embryogenesis and disease. Nat Rev Mol Cell Biol. 2002 Oct;3(10):753-66. doi: 10.1038/nrm934. PMID:12360192 doi:http://dx.doi.org/10.1038/nrm934
- ↑ Jaaks P, Bernasconi M. The proprotein convertase furin in tumour progression. Int J Cancer. 2017 Aug 15;141(4):654-663. doi: 10.1002/ijc.30714. Epub 2017 May, 15. PMID:28369813 doi:http://dx.doi.org/10.1002/ijc.30714
- ↑ Ren K, Jiang T, Zheng XL, Zhao GJ. Proprotein convertase furin/PCSK3 and atherosclerosis: New insights and potential therapeutic targets. Atherosclerosis. 2017 Jul;262:163-170. doi:, 10.1016/j.atherosclerosis.2017.04.005. Epub 2017 Apr 7. PMID:28400053 doi:http://dx.doi.org/10.1016/j.atherosclerosis.2017.04.005
- ↑ Coutard B, Valle C, de Lamballerie X, Canard B, Seidah NG, Decroly E. The spike glycoprotein of the new coronavirus 2019-nCoV contains a furin-like cleavage site absent in CoV of the same clade. Antiviral Res. 2020 Apr;176:104742. doi: 10.1016/j.antiviral.2020.104742. Epub, 2020 Feb 10. PMID:32057769 doi:http://dx.doi.org/10.1016/j.antiviral.2020.104742
