6lnm
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of CASK-CaMK in complex with Mint1-CID== | |
| - | + | <StructureSection load='6lnm' size='340' side='right'caption='[[6lnm]], [[Resolution|resolution]] 2.40Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6lnm]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6LNM OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6LNM FirstGlance]. <br> | |
| - | + | </td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6lnm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6lnm OCA], [http://pdbe.org/6lnm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6lnm RCSB], [http://www.ebi.ac.uk/pdbsum/6lnm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6lnm ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/CSKP_RAT CSKP_RAT]] Multidomain scaffolding protein with a role in synaptic transmembrane protein anchoring and ion channel trafficking. Contributes to neural development and regulation of gene expression via interaction with the transcription factor TRB1. Binds to cell-surface proteins, including amyloid precursor protein, neurexins, and syndecans. May mediate a link between the extracellular matrix and the actin cytoskeleton via its interaction with syndecan and with the actin/spectrin-binding protein 4.1.<ref>PMID:10749215</ref> [[http://www.uniprot.org/uniprot/APBA1_MOUSE APBA1_MOUSE]] Putative function in synaptic vesicle exocytosis by binding to Munc18-1, an essential component of the synaptic vesicle exocytotic machinery. May modulate processing of the amyloid-beta precursor protein (APP) and hence formation of AAP-beta (By similarity). | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Non-specific serine/threonine protein kinase]] | ||
| + | [[Category: Cai, Q]] | ||
| + | [[Category: Zhang, M]] | ||
| + | [[Category: Calmodulin-dependent protein kinase]] | ||
| + | [[Category: Camk]] | ||
| + | [[Category: Cask]] | ||
| + | [[Category: Lin-2]] | ||
| + | [[Category: Maguk]] | ||
| + | [[Category: Mint1]] | ||
| + | [[Category: Transferase]] | ||
Revision as of 06:49, 8 April 2020
Crystal structure of CASK-CaMK in complex with Mint1-CID
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