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5dgz

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==Discovery of 3,5-substituted 6-azaindazoles as potent pan-Pim inhibitors==
==Discovery of 3,5-substituted 6-azaindazoles as potent pan-Pim inhibitors==
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<StructureSection load='5dgz' size='340' side='right' caption='[[5dgz]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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<StructureSection load='5dgz' size='340' side='right'caption='[[5dgz]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5dgz]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5DGZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5DGZ FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5dgz]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5DGZ OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5DGZ FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=L20:(2S)-1-(1H-INDOL-3-YL)-3-{[5-(3-METHYL-1H-INDAZOL-5-YL)PYRIDIN-3-YL]OXY}PROPAN-2-AMINE'>L20</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=L20:(2S)-1-(1H-INDOL-3-YL)-3-{[5-(3-METHYL-1H-INDAZOL-5-YL)PYRIDIN-3-YL]OXY}PROPAN-2-AMINE'>L20</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5dhj|5dhj]], [[5dia|5dia]]</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5dhj|5dhj]], [[5dia|5dia]]</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5dgz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5dgz OCA], [http://pdbe.org/5dgz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5dgz RCSB], [http://www.ebi.ac.uk/pdbsum/5dgz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5dgz ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5dgz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5dgz OCA], [http://pdbe.org/5dgz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5dgz RCSB], [http://www.ebi.ac.uk/pdbsum/5dgz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5dgz ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Large Structures]]
[[Category: Non-specific serine/threonine protein kinase]]
[[Category: Non-specific serine/threonine protein kinase]]
[[Category: Murray, J M]]
[[Category: Murray, J M]]

Revision as of 08:03, 8 April 2020

Discovery of 3,5-substituted 6-azaindazoles as potent pan-Pim inhibitors

PDB ID 5dgz

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