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5flu

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Revision as of 19:52, 10 April 2020

Structure of a Chaperone-Usher pilus reveals the molecular basis of rod uncoilin

5flu, resolution 3.80Å

Structural highlights

5flu is a 13 chain structure with sequence from "bacillus_coli"_migula_1895 "bacillus coli" migula 1895. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Experimental data:	Check to display Experimental Data
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[PAPA_ECOLX] Polymerizes to form the thick (6.8 nm in diameter) rod of the pilus (also called fimbria). The rod is a right-handed helical cylinder with 3.28 PapA subunits per turn. Pili are polar filaments radiating from the surface of the bacterium to a length of 0.5-1.5 micrometers and numbering 100-300 per cell, and enable bacteria to colonize the epithelium of specific host organs.

Publication Abstract from PubMed

Types 1 and P pili are prototypical bacterial cell-surface appendages playing essential roles in mediating adhesion of bacteria to the urinary tract. These pili, assembled by the chaperone-usher pathway, are polymers of pilus subunits assembling into two parts: a thin, short tip fibrillum at the top, mounted on a long pilus rod. The rod adopts a helical quaternary structure and is thought to play essential roles: its formation may drive pilus extrusion by preventing backsliding of the nascent growing pilus within the secretion pore; the rod also has striking spring-like properties, being able to uncoil and recoil depending on the intensity of shear forces generated by urine flow. Here, we present an atomic model of the P pilus generated from a 3.8 A resolution cryo-electron microscopy reconstruction. This structure provides the molecular basis for the rod's remarkable mechanical properties and illuminates its role in pilus secretion.

Structure of a Chaperone-Usher Pilus Reveals the Molecular Basis of Rod Uncoiling.,Hospenthal MK, Redzej A, Dodson K, Ukleja M, Frenz B, Rodrigues C, Hultgren SJ, DiMaio F, Egelman EH, Waksman G Cell. 2015 Dec 22. pii: S0092-8674(15)01568-8. doi: 10.1016/j.cell.2015.11.049. PMID:26724865^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Hospenthal MK, Redzej A, Dodson K, Ukleja M, Frenz B, Rodrigues C, Hultgren SJ, DiMaio F, Egelman EH, Waksman G. Structure of a Chaperone-Usher Pilus Reveals the Molecular Basis of Rod Uncoiling. Cell. 2015 Dec 22. pii: S0092-8674(15)01568-8. doi: 10.1016/j.cell.2015.11.049. PMID:26724865 doi:http://dx.doi.org/10.1016/j.cell.2015.11.049

1 Structural highlights
2 Function
3 Publication Abstract from PubMed
4 See Also
5 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/5flu"

@@ Line 3: / Line 3: @@
 <SX load='5flu' size='340' side='right' viewer='molstar' caption='[[5flu]], [[Resolution|resolution]] 3.80&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[5flu]] is a 13 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FLU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5FLU FirstGlance]. <br>
+<table><tr><td colspan='2'>[[5flu]] is a 13 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FLU OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5FLU FirstGlance]. <br>
-</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5flu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5flu OCA], [http://pdbe.org/5flu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5flu RCSB], [http://www.ebi.ac.uk/pdbsum/5flu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5flu ProSAT]</span></td></tr>
+</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5flu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5flu OCA], [http://pdbe.org/5flu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5flu RCSB], [http://www.ebi.ac.uk/pdbsum/5flu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5flu ProSAT]</span></td></tr>
 </table>
 == Function ==

5flu

From Proteopedia

Revision as of 19:52, 10 April 2020

Structure of a Chaperone-Usher pilus reveals the molecular basis of rod uncoilin

Structural highlights

Function

Publication Abstract from PubMed

See Also

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

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