Tailspike protein
From Proteopedia
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== Structural highlights == | == Structural highlights == | ||
| - | The C-terminal domain (CTD) (residues 109-end) of TSP is responsible for the attachment of the tailspike protein to the O-antigen moiety on bacterial cell surface. The 3D structure of an <scene name='84/841073/Cv/3'>octasaccharide</scene> bound to CTP of TSP shows <scene name='84/841073/Cv/4'>numerous hydrophobic interactions as well as | + | The C-terminal domain (CTD) (residues 109-end) of TSP is responsible for the attachment of the tailspike protein to the O-antigen moiety on bacterial cell surface. The 3D structure of an <scene name='84/841073/Cv/3'>octasaccharide</scene> bound to CTP of TSP shows <scene name='84/841073/Cv/4'>numerous hydrophobic interactions as well as defined water molecules forming hydrogen bonds to the antigen</scene><ref>PMID:23292517</ref>. |
</StructureSection> | </StructureSection> | ||
Revision as of 12:30, 12 April 2020
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3D structures of tailspike protein
Updated on 12-April-2020
References
- ↑ Williams J, Venkatesan K, Ayariga JA, Jackson D, Wu H, Villafane R. A genetic analysis of an important hydrophobic interaction at the P22 tailspike protein N-terminal domain. Arch Virol. 2018 Jun;163(6):1623-1633. doi: 10.1007/s00705-018-3777-y. Epub 2018 , Mar 2. PMID:29500571 doi:http://dx.doi.org/10.1007/s00705-018-3777-y
- ↑ Andres D, Hanke C, Baxa U, Seul A, Barbirz S, Seckler R. Tailspike interactions with lipopolysaccharide effect DNA ejection from phage P22 particles in vitro. J Biol Chem. 2010 Nov 19;285(47):36768-75. doi: 10.1074/jbc.M110.169003. Epub, 2010 Sep 3. PMID:20817910 doi:http://dx.doi.org/10.1074/jbc.M110.169003
- ↑ Kunstmann S, Scheidt T, Buchwald S, Helm A, Mulard LA, Fruth A, Barbirz S. Bacteriophage Sf6 Tailspike Protein for Detection of Shigella flexneri Pathogens. Viruses. 2018 Aug 15;10(8). pii: v10080431. doi: 10.3390/v10080431. PMID:30111705 doi:http://dx.doi.org/10.3390/v10080431
- ↑ Andres D, Gohlke U, Broeker NK, Schulze S, Rabsch W, Heinemann U, Barbirz S, Seckler R. An essential serotype recognition pocket on phage P22 tailspike protein forces Salmonella enterica serovar Paratyphi A O-antigen fragments to bind as nonsolution conformers. Glycobiology. 2013 Apr;23(4):486-94. doi: 10.1093/glycob/cws224. Epub 2013 Jan 3. PMID:23292517 doi:http://dx.doi.org/10.1093/glycob/cws224
