6w41
From Proteopedia
(Difference between revisions)
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==Crystal structure of SARS-CoV-2 receptor binding domain in complex with human antibody CR3022== | ==Crystal structure of SARS-CoV-2 receptor binding domain in complex with human antibody CR3022== | ||
| - | < | + | <SX load='6w41' size='340' side='right' viewer='molstar' caption='[[6w41]], [[Resolution|resolution]] 3.08Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[6w41]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human] and [http://en.wikipedia.org/wiki/Wcpv Wcpv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6W41 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6W41 FirstGlance]. <br> | <table><tr><td colspan='2'>[[6w41]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human] and [http://en.wikipedia.org/wiki/Wcpv Wcpv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6W41 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6W41 FirstGlance]. <br> | ||
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6w41 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6w41 OCA], [http://pdbe.org/6w41 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6w41 RCSB], [http://www.ebi.ac.uk/pdbsum/6w41 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6w41 ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6w41 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6w41 OCA], [http://pdbe.org/6w41 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6w41 RCSB], [http://www.ebi.ac.uk/pdbsum/6w41 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6w41 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | The outbreak of COVID-19 caused by SARS-CoV-2 virus has now become a pandemic, but there is currently very little understanding of the antigenicity of the virus. We therefore determined the crystal structure of CR3022, a neutralizing antibody previously isolated from a convalescent SARS patient, in complex with the receptor-binding domain (RBD) of the SARS-CoV-2 spike (S) protein to 3.1 A. CR3022 targets a highly conserved epitope, distal from the receptor-binding site, that enables cross-reactive binding between SARS-CoV-2 and SARS-CoV. Structural modeling further demonstrates that the binding epitope can only be accessed by CR3022 when at least two RBD on the trimeric S protein are in the "up" conformation and slightly rotated. Overall, this study provides molecular insights into antibody recognition of SARS-CoV-2. | ||
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| + | A highly conserved cryptic epitope in the receptor-binding domains of SARS-CoV-2 and SARS-CoV.,Yuan M, Wu NC, Zhu X, Lee CD, So RTY, Lv H, Mok CKP, Wilson IA Science. 2020 Apr 3. pii: science.abb7269. doi: 10.1126/science.abb7269. PMID:32245784<ref>PMID:32245784</ref> | ||
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| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 6w41" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
| - | </ | + | </SX> |
[[Category: Human]] | [[Category: Human]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
Revision as of 05:03, 15 April 2020
Crystal structure of SARS-CoV-2 receptor binding domain in complex with human antibody CR3022
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Categories: Human | Large Structures | Wcpv | Wilson, I A | Wu, N C | Yuan, M | Zhu, X Y | Antibody | Complex | Immune system | Immune system-viral protein complex | Sars-cov-2 | Virus
