6v6d

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<StructureSection load='6v6d' size='340' side='right'caption='[[6v6d]], [[Resolution|resolution]] 3.77&Aring;' scene=''>
<StructureSection load='6v6d' size='340' side='right'caption='[[6v6d]], [[Resolution|resolution]] 3.77&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6v6d]] is a 7 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6V6D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6V6D FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6v6d]] is a 7 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6V6D OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6V6D FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6v6d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6v6d OCA], [http://pdbe.org/6v6d PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6v6d RCSB], [http://www.ebi.ac.uk/pdbsum/6v6d PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6v6d ProSAT]</span></td></tr>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PANX1, MRS1, UNQ2529/PRO6028 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6v6d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6v6d OCA], [http://pdbe.org/6v6d PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6v6d RCSB], [http://www.ebi.ac.uk/pdbsum/6v6d PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6v6d ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/PANX1_HUMAN PANX1_HUMAN]] Structural component of the gap junctions and the hemichannels. May play a role as a Ca(2+)-leak channel to regulate ER Ca(2+) homeostasis.<ref>PMID:16908669</ref> <ref>PMID:20829356</ref>
[[http://www.uniprot.org/uniprot/PANX1_HUMAN PANX1_HUMAN]] Structural component of the gap junctions and the hemichannels. May play a role as a Ca(2+)-leak channel to regulate ER Ca(2+) homeostasis.<ref>PMID:16908669</ref> <ref>PMID:20829356</ref>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The plasma membrane adenosine triphosphate (ATP) release channel pannexin 1 (PANX1) has been implicated in many physiological and pathophysiological processes associated with purinergic signaling, including cancer progression, apoptotic cell clearance, inflammation, blood pressure regulation, oocyte development, epilepsy and neuropathic pain. Here we present near-atomic-resolution structures of human and frog PANX1 determined by cryo-electron microscopy that revealed a heptameric channel architecture. Compatible with ATP permeation, the transmembrane pore and cytoplasmic vestibule were exceptionally wide. An extracellular tryptophan ring located at the outer pore created a constriction site, potentially functioning as a molecular sieve that restricts the size of permeable substrates. The amino and carboxyl termini, not resolved in the density map, appeared to be structurally dynamic and might contribute to narrowing of the pore during channel gating. In combination with functional characterization, this work elucidates the previously unknown architecture of pannexin channels and establishes a foundation for understanding their unique channel properties.
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Cryo-EM structures of the ATP release channel pannexin 1.,Deng Z, He Z, Maksaev G, Bitter RM, Rau M, Fitzpatrick JAJ, Yuan P Nat Struct Mol Biol. 2020 Apr;27(4):373-381. doi: 10.1038/s41594-020-0401-0. Epub, 2020 Mar 30. PMID:32231289<ref>PMID:32231289</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 6v6d" style="background-color:#fffaf0;"></div>
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Deng, Z]]
[[Category: Deng, Z]]

Revision as of 07:20, 15 April 2020

Cryo-EM structure of human pannexin 1

PDB ID 6v6d

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