2jln

From Proteopedia

(Difference between revisions)

Revision as of 07:55, 15 April 2020

Structure of Mhp1, a nucleobase-cation-symport-1 family transporter

Structural highlights

2jln is a 1 chain structure with sequence from "microbacterium_liquefaciens"_orla-jensen_1919 "microbacterium liquefaciens" orla-jensen 1919. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:	,
Related:	2jlo
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

The 'Nucleobase-Cation-Symport-1', NCS1, transporters are essential components of salvage pathways for nucleobases and related metabolites. Here, we report the 2.85 A resolution structure of the NCS1 benzyl-hydantoin transporter, Mhp1, from Microbacterium liquefaciens. Mhp1 contains 12 transmembrane helices, 10 of which are arranged in two inverted repeats of 5 helices. The structures of the outward-facing open and substrate-bound occluded conformations were solved, showing how the outward-facing cavity closes upon binding of substrate. Comparisons with the leucine (LeuTAa) and the galactose (vSGLT) transporters reveal that the outward- and inward-facing cavities are symmetrically arranged on opposite sides of the membrane. The reciprocal opening and closing of these cavities is synchronised by the inverted repeat helices 3 and 8, providing the structural basis of the 'alternating access' model for membrane transport.

Structure and Molecular Mechanism of a Nucleobase-Cation-Symport-1 Family Transporter.,Weyand S, Shimamura T, Yajima S, Suzuki S, Mirza O, Krusong K, Carpenter EP, Rutherford NG, Hadden JM, O'Reilly J, Ma P, Saidijam M, Patching SG, Hope RJ, Norbertczak HT, Roach PC, Iwata S, Henderson PJ, Cameron AD Science. 2008 Oct 16. PMID:18927357^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Weyand S, Shimamura T, Yajima S, Suzuki S, Mirza O, Krusong K, Carpenter EP, Rutherford NG, Hadden JM, O'Reilly J, Ma P, Saidijam M, Patching SG, Hope RJ, Norbertczak HT, Roach PC, Iwata S, Henderson PJ, Cameron AD. Structure and Molecular Mechanism of a Nucleobase-Cation-Symport-1 Family Transporter. Science. 2008 Oct 16. PMID:18927357

1 Structural highlights
2 Evolutionary Conservation
3 Publication Abstract from PubMed
4 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2jln"

@@ Line 1: / Line 1: @@
 ==Structure of Mhp1, a nucleobase-cation-symport-1 family transporter==
-<StructureSection load='2jln' size='340' side='right' caption='[[2jln]], [[Resolution|resolution]] 2.85&Aring;' scene=''>
+<StructureSection load='2jln' size='340' side='right'caption='[[2jln]], [[Resolution|resolution]] 2.85&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[2jln]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"microbacterium_liquefaciens"_orla-jensen_1919 "microbacterium liquefaciens" orla-jensen 1919]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JLN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JLN FirstGlance]. <br>
+<table><tr><td colspan='2'>[[2jln]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"microbacterium_liquefaciens"_orla-jensen_1919 "microbacterium liquefaciens" orla-jensen 1919]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JLN OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2JLN FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HG:MERCURY+(II)+ION'>HG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HG:MERCURY+(II)+ION'>HG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
 <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2jlo|2jlo]]</td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jln FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jln OCA], [http://pdbe.org/2jln PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2jln RCSB], [http://www.ebi.ac.uk/pdbsum/2jln PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2jln ProSAT]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2jln FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jln OCA], [http://pdbe.org/2jln PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2jln RCSB], [http://www.ebi.ac.uk/pdbsum/2jln PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2jln ProSAT]</span></td></tr>
 </table>
 == Evolutionary Conservation ==
@@ Line 32: / Line 32: @@
 </StructureSection>
 [[Category: Microbacterium liquefaciens orla-jensen 1919]]
+[[Category: Large Structures]]
 [[Category: Cameron, A D]]
 [[Category: Carpenter, E P]]

2jln

From Proteopedia

Revision as of 07:55, 15 April 2020

Structure of Mhp1, a nucleobase-cation-symport-1 family transporter

Structural highlights

Evolutionary Conservation

Publication Abstract from PubMed

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

Views

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