1b4f

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[[Image:1b4f.jpg|left|200px]]
[[Image:1b4f.jpg|left|200px]]
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{{Structure
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The line below this paragraph, containing "STRUCTURE_1b4f", creates the "Structure Box" on the page.
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{{STRUCTURE_1b4f| PDB=1b4f | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1b4f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1b4f OCA], [http://www.ebi.ac.uk/pdbsum/1b4f PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1b4f RCSB]</span>
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'''OLIGOMERIC STRUCTURE OF THE HUMAN EPHB2 RECEPTOR SAM DOMAIN'''
'''OLIGOMERIC STRUCTURE OF THE HUMAN EPHB2 RECEPTOR SAM DOMAIN'''
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[[Category: Goodwill, K E.]]
[[Category: Goodwill, K E.]]
[[Category: Thanos, C D.]]
[[Category: Thanos, C D.]]
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[[Category: eph receptor]]
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[[Category: Eph receptor]]
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[[Category: oligomer]]
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[[Category: Oligomer]]
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[[Category: sam domain]]
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[[Category: Sam domain]]
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[[Category: signal transduction]]
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[[Category: Signal transduction]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 11:03:19 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 18:53:23 2008''
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Revision as of 08:03, 2 May 2008

Image:1b4f.jpg

Template:STRUCTURE 1b4f

OLIGOMERIC STRUCTURE OF THE HUMAN EPHB2 RECEPTOR SAM DOMAIN


Overview

The sterile alpha motif (SAM) domain is a protein interaction module that is present in diverse signal-transducing proteins. SAM domains are known to form homo- and hetero-oligomers. The crystal structure of the SAM domain from an Eph receptor tyrosine kinase, EphB2, reveals two large interfaces. In one interface, adjacent monomers exchange amino-terminal peptides that insert into a hydrophobic groove on each neighbor. A second interface is composed of the carboxyl-terminal helix and a nearby loop. A possible oligomer, constructed from a combination of these binding modes, may provide a platform for the formation of larger protein complexes.

About this Structure

1B4F is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Oligomeric structure of the human EphB2 receptor SAM domain., Thanos CD, Goodwill KE, Bowie JU, Science. 1999 Feb 5;283(5403):833-6. PMID:9933164 Page seeded by OCA on Fri May 2 11:03:19 2008

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