6kny
From Proteopedia
(Difference between revisions)
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==Structure of Amuc_1100 without transmembrane region from Akkermansia muciniphila== | ==Structure of Amuc_1100 without transmembrane region from Akkermansia muciniphila== | ||
| - | <StructureSection load='6kny' size='340' side='right'caption='[[6kny]]' scene=''> | + | <StructureSection load='6kny' size='340' side='right'caption='[[6kny]], [[Resolution|resolution]] 2.10Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6KNY OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6KNY FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[6kny]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Akkm8 Akkm8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6KNY OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6KNY FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6kny FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6kny OCA], [http://pdbe.org/6kny PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6kny RCSB], [http://www.ebi.ac.uk/pdbsum/6kny PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6kny ProSAT]</span></td></tr> | + | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Amuc_1100 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=349741 AKKM8])</td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6kny FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6kny OCA], [http://pdbe.org/6kny PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6kny RCSB], [http://www.ebi.ac.uk/pdbsum/6kny PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6kny ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Many human diseases, such as obesity and diabetes, show annual increases in prevalence and often involve intestinal microbes. One such probiotic bacterium, Akkermansia muciniphila, which was discovered a decade ago, has been reported to influence glucose homeostasis and to contribute to gut health. Amuc_1100, a functionally uncharacterized protein of A. muciniphila, was found to be a key active component in reducing the body weight of mice. Here, the crystal structure of Amuc_1100 (residues 31-317), referred to as Amuc_1100*, is reported at 2.1 A resolution. Amuc_1100* has a similar fold to three proteins related to pilus formation, PilO, PilN and EpsL, indicating a similar function. Biochemical investigations further confirmed a monomeric state for the soluble region of Amuc_1100, which differs from the dimeric states of PilO, PilN and EpsL. This study provides a structural basis for the elucidation of the molecular mechanism of Amuc_1100. | ||
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| + | Crystal structure of monomeric Amuc_1100 from Akkermansia muciniphila.,Mou L, Peng X, Chen Y, Xiao Q, Liao H, Liu M, Guo L, Liu Y, Zhang X, Deng D Acta Crystallogr F Struct Biol Commun. 2020 Apr 1;76(Pt 4):168-174. doi:, 10.1107/S2053230X20004124. Epub 2020 Apr 1. PMID:32254050<ref>PMID:32254050</ref> | ||
| + | |||
| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 6kny" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Akkm8]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Deng D]] | + | [[Category: Deng, D]] |
| - | [[Category: Mou | + | [[Category: Mou, L Q]] |
| - | [[Category: Xiao | + | [[Category: Xiao, Q J]] |
| + | [[Category: Protein]] | ||
| + | [[Category: Uncharacterized]] | ||
| + | [[Category: Unknown function]] | ||
Revision as of 06:01, 22 April 2020
Structure of Amuc_1100 without transmembrane region from Akkermansia muciniphila
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