5eig

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==Engineered human cystathionine gamma lyase (E59T, E339V) to deplet cysteine==
==Engineered human cystathionine gamma lyase (E59T, E339V) to deplet cysteine==
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<StructureSection load='5eig' size='340' side='right' caption='[[5eig]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
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<StructureSection load='5eig' size='340' side='right'caption='[[5eig]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5eig]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EIG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5EIG FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5eig]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EIG OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5EIG FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CYS:CYSTEINE'>CYS</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CYS:CYSTEINE'>CYS</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=5OW:(2~{S})-2-AZANYL-6-[[(~{Z})-~{C}-[2-METHYL-3-OXIDANYL-5-(PHOSPHONOOXYMETHYL)PYRIDIN-4-YL]-~{N}-[(2~{R})-1-OXIDANYL-1-OXIDANYLIDENE-3-SULFANYL-PROPAN-2-YL]CARBONIMIDOYL]AMINO]HEXANOIC+ACID'>5OW</scene>, <scene name='pdbligand=LLP:(2S)-2-AMINO-6-[[3-HYDROXY-2-METHYL-5-(PHOSPHONOOXYMETHYL)PYRIDIN-4-YL]METHYLIDENEAMINO]HEXANOIC+ACID'>LLP</scene></td></tr>
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=5OW:(2~{S})-2-AZANYL-6-[[(~{Z})-~{C}-[2-METHYL-3-OXIDANYL-5-(PHOSPHONOOXYMETHYL)PYRIDIN-4-YL]-~{N}-[(2~{R})-1-OXIDANYL-1-OXIDANYLIDENE-3-SULFANYL-PROPAN-2-YL]CARBONIMIDOYL]AMINO]HEXANOIC+ACID'>5OW</scene>, <scene name='pdbligand=LLP:(2S)-2-AMINO-6-[[3-HYDROXY-2-METHYL-5-(PHOSPHONOOXYMETHYL)PYRIDIN-4-YL]METHYLIDENEAMINO]HEXANOIC+ACID'>LLP</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CTH ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cystathionine_gamma-lyase Cystathionine gamma-lyase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.4.1.1 4.4.1.1] </span></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cystathionine_gamma-lyase Cystathionine gamma-lyase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.4.1.1 4.4.1.1] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5eig FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5eig OCA], [http://pdbe.org/5eig PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5eig RCSB], [http://www.ebi.ac.uk/pdbsum/5eig PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5eig ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5eig FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5eig OCA], [http://pdbe.org/5eig PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5eig RCSB], [http://www.ebi.ac.uk/pdbsum/5eig PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5eig ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
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</StructureSection>
</StructureSection>
[[Category: Cystathionine gamma-lyase]]
[[Category: Cystathionine gamma-lyase]]
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[[Category: Human]]
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[[Category: Large Structures]]
[[Category: Yan, W]]
[[Category: Yan, W]]
[[Category: Zhang, J]]
[[Category: Zhang, J]]
[[Category: Lyase]]
[[Category: Lyase]]

Revision as of 06:59, 22 April 2020

Engineered human cystathionine gamma lyase (E59T, E339V) to deplet cysteine

PDB ID 5eig

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