Rhodocetin
From Proteopedia
(Difference between revisions)
(New page: <StructureSection load='5thp' size='340' side='right' describing Jmol <ref>PMID:21638687</ref> to the rescue. == Function == '''Rhodocetin''' ((Rtn) == Disease == == Relevance == == ...) |
|||
| Line 1: | Line 1: | ||
| - | + | <StructureSection load='3gpr' size='340' side='right' describing | |
| - | <StructureSection load=' | + | |
== Function == | == Function == | ||
| - | '''Rhodocetin''' | + | '''Rhodocetin''' (Rtn) is a platelet aggregation inhibitor produced by the Malayan pit viper<ref>PMID:10360956</ref>. |
| - | == | + | == Relevance == |
| - | + | Rhodocetin subunits αβ which selectively attacks tumor blood vessels and spares normal tissue vessels is studied as an anti-tumor<ref>PMID:29854288</ref>. | |
== Structural highlights == | == Structural highlights == | ||
Revision as of 08:18, 23 April 2020
| |||||||||||
3D structures of rhodocetin
Updated on 23-April-2020
1sb2 - MpvRtn subunits αβ - Malayan pit viper
3gpr - MpvRtn subunits αβγδ
6nde, 6ndd, 6ndf, 6ndh, 6nda, 6ndc, 6ndb, 6nd8, 6ndg, 6nd9, 5thp - MpvRtn subunits γδ + integrin α-2 + ion
References
- ↑ Niland S, Komljenovic D, Macas J, Bracht T, Bauerle T, Liebner S, Eble JA. Rhodocetin-alphabeta selectively breaks the endothelial barrier of the tumor vasculature in HT1080 fibrosarcoma and A431 epidermoid carcinoma tumor models. Oncotarget. 2018 Apr 27;9(32):22406-22422. doi: 10.18632/oncotarget.25032., eCollection 2018 Apr 27. PMID:29854288 doi:http://dx.doi.org/10.18632/oncotarget.25032
