Vm24 Scorpion Toxin
From Proteopedia
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[[Image:V24 APBS.png|300px|thumb|upright|left|alt=alt|APBS Electrostatic Surface of Vm24, [[2k9o]]]] | [[Image:V24 APBS.png|300px|thumb|upright|left|alt=alt|APBS Electrostatic Surface of Vm24, [[2k9o]]]] | ||
<Structure load='2k9o' size='350' frame='true' align='right' caption='Vm24 Scorpion Toxin [[2k9o]]' scene='Insert optional scene name here' /> | <Structure load='2k9o' size='350' frame='true' align='right' caption='Vm24 Scorpion Toxin [[2k9o]]' scene='Insert optional scene name here' /> | ||
| + | ==Protein Source== | ||
| + | Gurolla G.B et al ***link*** isolated the peptide components of ''Vaejovis mexicanus smithi" venom using high-performance liquid chromatography. Over 200 components were identified. The structure of Vm24 was determined by solution NMR spectroscopy, and it was sequenced via trypsin digestion. The a synthetic Vm24 gene was created and artificially translated to produce the synthetic Vm24 toxin displayed. | ||
Revision as of 19:00, 24 April 2020
Introduction
Vm24 synthetic scorpion toxin is a peptide toxin isolated from Vaejovis mexicanus scorpion venom. It is a potent inhibitor of Kv1.3 potassium channels of human T lymphocytes. Its high affinity and specificity for human lymphocytes makes it a candidate for the treatment of several autoimmune disorders.
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Protein Source
Gurolla G.B et al ***link*** isolated the peptide components of Vaejovis mexicanus smithi" venom using high-performance liquid chromatography. Over 200 components were identified. The structure of Vm24 was determined by solution NMR spectroscopy, and it was sequenced via trypsin digestion. The a synthetic Vm24 gene was created and artificially translated to produce the synthetic Vm24 toxin displayed.
