Vm24 Scorpion Toxin
From Proteopedia
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<Structure load='2k9o' size='350' frame='true' align='right' caption='Vm24 Scorpion Toxin [[2k9o]]' scene='Insert optional scene name here' /> | <Structure load='2k9o' size='350' frame='true' align='right' caption='Vm24 Scorpion Toxin [[2k9o]]' scene='Insert optional scene name here' /> | ||
==Protein Source== | ==Protein Source== | ||
| - | Gurolla G.B et al ***link*** isolated the peptide components of ''Vaejovis mexicanus smithi | + | Gurolla G.B et al ***link*** isolated the peptide components of ''Vaejovis mexicanus smithi'' venom using high-performance liquid chromatography. Over 200 components were identified. The structure of Vm24 was determined by solution NMR spectroscopy, and it was sequenced via trypsin digestion. The a synthetic Vm24 gene was created and artificially translated to produce the synthetic Vm24 toxin displayed. |
Revision as of 19:01, 24 April 2020
Introduction
Vm24 synthetic scorpion toxin is a peptide toxin isolated from Vaejovis mexicanus scorpion venom. It is a potent inhibitor of Kv1.3 potassium channels of human T lymphocytes. Its high affinity and specificity for human lymphocytes makes it a candidate for the treatment of several autoimmune disorders.
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Protein Source
Gurolla G.B et al ***link*** isolated the peptide components of Vaejovis mexicanus smithi venom using high-performance liquid chromatography. Over 200 components were identified. The structure of Vm24 was determined by solution NMR spectroscopy, and it was sequenced via trypsin digestion. The a synthetic Vm24 gene was created and artificially translated to produce the synthetic Vm24 toxin displayed.
