Adaptin
From Proteopedia
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<StructureSection load='2vgl' size='350' side='right' caption='Structure of Adaptin core: AP-α-2 (cyan), AP-β-1 (magenta), AP-μ-1 (green), AP-σ-1 (olive) complex with inositole hexakisphosphate (PDB entry [[2vgl]])' scene='55/559108/Cv/1'> | <StructureSection load='2vgl' size='350' side='right' caption='Structure of Adaptin core: AP-α-2 (cyan), AP-β-1 (magenta), AP-μ-1 (green), AP-σ-1 (olive) complex with inositole hexakisphosphate (PDB entry [[2vgl]])' scene='55/559108/Cv/1'> | ||
| - | '''Adaptin''' (AP) are proteins which mediate the formation of vescicles by clathrin-coated pits. The AP complex is a heterotetramer composed of 2 '''large AP''': AP-α or AP-γ and AP-β, a '''medium-size AP''': AP-μ and '''small AP''': AP-σ. AP complexes connect proteins and lipids to clathrin budding sites. There are different AP complexes in mammals.<ref name="Ad">PMID:12086608</ref> | + | '''Adaptin''' (AP) are proteins which mediate the formation of vescicles by clathrin-coated pits. The '''AP-2 complex''' is a heterotetramer composed of 2 '''large AP''': AP-α or AP-γ and AP-β, a '''medium-size AP''': AP-μ and '''small AP''': AP-σ. AP complexes connect proteins and lipids to clathrin budding sites. There are different AP complexes in mammals.<ref name="Ad">PMID:12086608</ref> |
*<scene name='55/559108/Cv/3'>Adaptin core: AP-α-2, AP-β-1, AP-μ-1, AP-σ-1 complex with inositole hexakisphosphate</scene>. | *<scene name='55/559108/Cv/3'>Adaptin core: AP-α-2, AP-β-1, AP-μ-1, AP-σ-1 complex with inositole hexakisphosphate</scene>. | ||
*<scene name='55/559108/Cv/6'>Inositole hexakisphosphate binding site</scene> ([[2vgl]]).<ref name="Ad">PMID:12086608</ref> | *<scene name='55/559108/Cv/6'>Inositole hexakisphosphate binding site</scene> ([[2vgl]]).<ref name="Ad">PMID:12086608</ref> | ||
Revision as of 15:13, 25 April 2020
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