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Miraculin is a protein that is best known for its ability to deceive human taste buds into thinking
Miraculin is a protein that is best known for its ability to deceive human taste buds into thinking
sour or acidic food is sweet. This homodimeric glycoprotein was first identified in the West
sour or acidic food is sweet. This homodimeric glycoprotein was first identified in the West
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African native fruit, Synsepalum dulcificum (also known as “Miracle Fruit”), and exists in the
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African native fruit, ''Synsepalum dulcificum'' (also known as “Miracle Fruit”), and exists in the
pulp of the miracle fruit.
pulp of the miracle fruit.
Miraculin’s deceptive properties have been exploited by several companies as sugar substitutes.
Miraculin’s deceptive properties have been exploited by several companies as sugar substitutes.
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== <h4><span style="color: purple;"> What We Know About Miraculin’s Structure </span></h4> ==
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== <h4><span style="color: purple;"> Miraculin’s Structure </span></h4> ==
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Miraculin is composed of 191 amino acid residues linked primarily by disulfide bonds,
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Miraculin is composed of 191 amino acid residues linked primarily by peptide bonds,
having a molecular weight of about 28 kDa. Sarroch Theerasil et al <ref>
having a molecular weight of about 28 kDa. Sarroch Theerasil et al <ref>
https://www.jbc.org/content/263/23/11536.full.pdf+html </ref> use HPLC profiles and SDS-PAGE
https://www.jbc.org/content/263/23/11536.full.pdf+html </ref> use HPLC profiles and SDS-PAGE

Revision as of 05:05, 26 April 2020

Miraculin, a taste-deceiving protein

PDB ID 3IIR

Drag the structure with the mouse to rotate

PDB ID 3IIR

Drag the structure with the mouse to rotate

References

  1. Hanson, R. M., Prilusky, J., Renjian, Z., Nakane, T. and Sussman, J. L. (2013), JSmol and the Next-Generation Web-Based Representation of 3D Molecular Structure as Applied to Proteopedia. Isr. J. Chem., 53:207-216. doi:http://dx.doi.org/10.1002/ijch.201300024
  2. Herraez A. Biomolecules in the computer: Jmol to the rescue. Biochem Mol Biol Educ. 2006 Jul;34(4):255-61. doi: 10.1002/bmb.2006.494034042644. PMID:21638687 doi:10.1002/bmb.2006.494034042644
  3. https://www.accessdata.fda.gov/cms_ia/importalert_120.html
  4. https://www.jbc.org/content/263/23/11536.full.pdf+html

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Fujr Ibrahim

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