Davis L. Martinec/Sandbox 4eqv
From Proteopedia
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Yeast invertase was first isolated in 1860 by Berthelot, but had been alluded to by Dubrunfaut in 1847.<ref>DOI: 10.1074/jbc.M112.446435 </ref> Invertase was posited to be an intracellular enzymee, yet de la Fuente and Sols were able to show that invertase can be excreted by the cell, thus it is also extracellular<ref>https://doi.org/10.1016/0006-3002(62)90526-7</ref>. The intracellular form of the enzyme is not glycosylated, while the extracellular form is extensively glycosylated<ref name="3d" />. The same gene codes for glycosylated and non-glycosylated forms of the enzyme they differ when being transcribed into mRNA, and the extracellular bound SInv is tagged with a signal peptide.<ref>https://doi.org/10.1007/BF00425540</ref> | Yeast invertase was first isolated in 1860 by Berthelot, but had been alluded to by Dubrunfaut in 1847.<ref>DOI: 10.1074/jbc.M112.446435 </ref> Invertase was posited to be an intracellular enzymee, yet de la Fuente and Sols were able to show that invertase can be excreted by the cell, thus it is also extracellular<ref>https://doi.org/10.1016/0006-3002(62)90526-7</ref>. The intracellular form of the enzyme is not glycosylated, while the extracellular form is extensively glycosylated<ref name="3d" />. The same gene codes for glycosylated and non-glycosylated forms of the enzyme they differ when being transcribed into mRNA, and the extracellular bound SInv is tagged with a signal peptide.<ref>https://doi.org/10.1007/BF00425540</ref> | ||
| - | Though it is an octamer, SInv can be best described as a tetramer of dimers<ref name="3d" />. The <scene name='84/842891/Labeled_chains/2'>labeled structure</scene> | + | Though it is an octamer, SInv can be best described as a tetramer of dimers<ref name="3d" />. The <scene name='84/842891/Labeled_chains/2'>labeled structure of SInv</scene> illustrates this high degree of symmetry. It should also be pointed out that the A/B and C/D dimers have been dubbed "closed" while the E/F and G/H dimers have been dubbed "open"<ref name="3d" />. |
== Structure == | == Structure == | ||
Revision as of 00:23, 27 April 2020
4EQV - Saccharomyces Invertase
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