User:Oluwapeluwa Sangoseni/Sandbox 1

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<table><tr><td colspan='2'> '''6P9U''' is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6P9U 6P9U]. For a <b>guided tour on the structure components</b>, use [https://proteopedia.org/wiki/fgij/fg.htm?mol=6P9U FirstGlance]. <br>
<table><tr><td colspan='2'> '''6P9U''' is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6P9U 6P9U]. For a <b>guided tour on the structure components</b>, use [https://proteopedia.org/wiki/fgij/fg.htm?mol=6P9U FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='x'>NAG</scene>, <scene name='y'>ZN</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">F2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">F2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Thrombin Thrombin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.5 3.4.21.5] </span></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Thrombin Thrombin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.5 3.4.21.5] </span></td></tr>

Revision as of 03:53, 28 April 2020

6P9U, Crystal Structure of Human Thrombin Mutant W215A

6P9U, resolution 3.38Å

Drag the structure with the mouse to rotate

References

  1. 1.0 1.1 Le Bonniec, B. F., &Walenga, J. M. (n.d.). Thrombin. Retrieved March 22, 2020, from https://www.sciencedirect.com/topics/medicine-and-dentistry/thrombin
  2. Narayanan S., Multifunctional roles of thrombin., Ann Clin Lab Sci., 1999; 29: 275-280
  3. Pelc, L.a., et al. “Crystal Structure of Human Thrombin Mutant W215A.” 2019, doi:10.2210/pdb6p9u/pdb.
  4. 4.0 4.1 Pelc, L. A., Koester, S. K., Chen, Z., Gistover, N. E., & Di Cera, E. (2019). Residues W215, E217 and E192 control the allosteric E*-E equilibrium of thrombin. Scientific reports, 9(1), 12304. https://doi.org/10.1038/s41598-019-48839-1
  5. Bunce, M. W., Toso, R., &Camire, R. M. (2011). Zymogen-like factor Xa variants restore thrombin generation and effectively bypass the intrinsic pathway in vitro. Blood, 117(1), 290–298. https://doi.org/10.1182/blood-2010-08-300756
  6. 6.0 6.1 6.2 6.3 6.4 Berny-Lang, M. A., Hurst, S., Tucker, E. I., Pelc, L. A., Wang, R. K., Hurn, P. D., Di Cera, E., McCarty, O. J., & Gruber, A. (2011). Thrombin mutant W215A/E217A treatment improves neurological outcome and reduces cerebral infarct size in a mouse model of ischemic stroke. Stroke, 42(6), 1736–1741. https://doi.org/10.1161/STROKEAHA.110.603811
  7. The Internet Stroke Center. (n.d.). Retrieved March 22, 2020, from http://www.strokecenter.org/patients/about-stroke/ischemic-stroke/
  8. Gruber, A., Cantwell, A. M., Cera, E. D., & Hanson, S. R. (2002). The Thrombin Mutant W215A/E217A Shows Safe and Potent Anticoagulant and Antithrombotic Effectsin Vivo. Journal of Biological Chemistry,277(31), 27581-27584. doi:10.1074/jbc.c200237200

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Oluwapeluwa Sangoseni

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