Adenomatous polyposis coli

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Revision as of 19:49, 28 April 2020

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Adenomatous polyposis coli

spinqualitylabelsall models Caption for this structure Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image Adenomatous polyposis coli (APC) is a multidomain tumour suppressor protein involved in the regulation of various cellular processes, such as cell adhesion, migration or proliferation[1]. It is expressed in plethora of organs and tissues, e. g. cerebral cortex, bronchi or the gastrointestinal tract[2]. Germline truncation mutations of APC result in familial adenomatous polyposis, a hereditary form of colon cancer[3]. Additionally, loss of the C-terminal portion of APC is detected in about 80 % of sporadic colon cancers[4]. Contents 1 Function 2 Disease 3 Relevance 4 Structural highlights Function Disease Relevance Structural highlights This is a sample scene created with SAT to by Group, and another to make of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.

References

1. ↑ Zhang, L. and Shay, J. W. (2017) ‘Multiple Roles of APC and its Therapeutic Implications in Colorectal Cancer.’, Journal of the National Cancer Institute, 109(8). doi: 10.1093/jnci/djw332.
2. ↑ https://www.proteinatlas.org/ENSG00000134982-APC/tissue
3. ↑ Ficari, F. et al. (2000) ‘APC gene mutations and colorectal adenomatosis in familial adenomatous polyposis’, British Journal of Cancer. Churchill Livingstone, 82(2), pp. 348–353. doi: 10.1054/bjoc.1999.0925.
4. ↑ Rowan, A. J. et al. (2000) ‘APC mutations in sporadic colorectal tumors: A mutational “hotspot” and interdependence of the “two hits”’, Proceedings of the National Academy of Sciences of the United States of America. National Academy of Sciences, 97(7), pp. 3352–3357. doi: 10.1073/pnas.97.7.3352.