5fbx
From Proteopedia
(Difference between revisions)
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==Crystal structure of the first bromodomain of human BRD4 in complex with PNZ5 isoxazole inhibitor== | ==Crystal structure of the first bromodomain of human BRD4 in complex with PNZ5 isoxazole inhibitor== | ||
| - | <StructureSection load='5fbx' size='340' side='right' caption='[[5fbx]], [[Resolution|resolution]] 1.85Å' scene=''> | + | <StructureSection load='5fbx' size='340' side='right'caption='[[5fbx]], [[Resolution|resolution]] 1.85Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[5fbx]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FBX OCA]. For a <b>guided tour on the structure components</b> use [http:// | + | <table><tr><td colspan='2'>[[5fbx]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FBX OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5FBX FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=5W4:(3~{S})-5-(3,5-DIMETHYL-1,2-OXAZOL-4-YL)-2-METHYL-3-PHENYL-3~{H}-ISOINDOL-1-ONE'>5W4</scene></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5W4:(3~{S})-5-(3,5-DIMETHYL-1,2-OXAZOL-4-YL)-2-METHYL-3-PHENYL-3~{H}-ISOINDOL-1-ONE'>5W4</scene></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http:// | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">BRD4, HUNK1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5fbx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fbx OCA], [http://pdbe.org/5fbx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5fbx RCSB], [http://www.ebi.ac.uk/pdbsum/5fbx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5fbx ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Disease == | == Disease == | ||
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== Function == | == Function == | ||
[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity). | [[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity). | ||
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| + | ==See Also== | ||
| + | *[[Bromodomain-containing protein 3D structures|Bromodomain-containing protein 3D structures]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Human]] | ||
| + | [[Category: Large Structures]] | ||
[[Category: Arrowsmith, C H]] | [[Category: Arrowsmith, C H]] | ||
[[Category: Bountra, C]] | [[Category: Bountra, C]] | ||
Revision as of 08:09, 29 April 2020
Crystal structure of the first bromodomain of human BRD4 in complex with PNZ5 isoxazole inhibitor
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Categories: Human | Large Structures | Arrowsmith, C H | Bountra, C | Brennan, P E | Clark, P G.K | Delft, F von | Dixon, D | Edwards, A M | Fedorov, O | Knapp, S | Muller, S | Nowak, R | Siejka, P | Srikannathasan, V | Tallant, C | Baf180 | Brg1-associated factor 180 | Chromatin remodeling | Transcription
