1b7f

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[[Image:1b7f.gif|left|200px]]
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{{Structure
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The line below this paragraph, containing "STRUCTURE_1b7f", creates the "Structure Box" on the page.
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|LIGAND= <scene name='pdbligand=G:GUANOSINE-5&#39;-MONOPHOSPHATE'>G</scene>, <scene name='pdbligand=U:URIDINE-5&#39;-MONOPHOSPHATE'>U</scene>
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{{STRUCTURE_1b7f| PDB=1b7f | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1b7f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1b7f OCA], [http://www.ebi.ac.uk/pdbsum/1b7f PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1b7f RCSB]</span>
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'''SXL-LETHAL PROTEIN/RNA COMPLEX'''
'''SXL-LETHAL PROTEIN/RNA COMPLEX'''
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[[Category: Shimura, Y.]]
[[Category: Shimura, Y.]]
[[Category: Yokoyama, S.]]
[[Category: Yokoyama, S.]]
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[[Category: riken structural genomics/proteomics initiative]]
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[[Category: Riken structural genomics/proteomics initiative]]
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[[Category: rna complex]]
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[[Category: Rna complex]]
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[[Category: rnp domain]]
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[[Category: Rnp domain]]
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[[Category: rsgi]]
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[[Category: Rsgi]]
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[[Category: splicing regulation]]
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[[Category: Splicing regulation]]
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[[Category: structural genomic]]
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[[Category: Structural genomic]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 18:55:15 2008''
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Revision as of 08:09, 2 May 2008

Image:1b7f.gif

Template:STRUCTURE 1b7f

SXL-LETHAL PROTEIN/RNA COMPLEX


Overview

The Sex-lethal (Sxl) protein of Drosophila melanogaster regulates alternative splicing of the transformer (tra) messenger RNA precursor by binding to the tra polypyrimidine tract during the sex-determination process. The crystal structure has now been determined at 2.6 A resolution of the complex formed between two tandemly arranged RNA-binding domains of the Sxl protein and a 12-nucleotide, single-stranded RNA derived from the tra polypyrimidine tract. The two RNA-binding domains have their beta-sheet platforms facing each other to form a V-shaped cleft. The RNA is characteristically extended and bound in this cleft, where the UGUUUUUUU sequence is specifically recognized by the protein. This structure offers the first insight, to our knowledge, into how a protein binds specifically to a cognate RNA without any intramolecular base-pairing.

About this Structure

1B7F is a Single protein structure of sequence from Drosophila melanogaster. Full crystallographic information is available from OCA.

Reference

Structural basis for recognition of the tra mRNA precursor by the Sex-lethal protein., Handa N, Nureki O, Kurimoto K, Kim I, Sakamoto H, Shimura Y, Muto Y, Yokoyama S, Nature. 1999 Apr 15;398(6728):579-85. PMID:10217141 Page seeded by OCA on Fri May 2 11:09:55 2008

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