5fiy

From Proteopedia

(Difference between revisions)

Revision as of 07:21, 6 May 2020

crystal structure of coiled coil domain of PAWR

Structural highlights

5fiy is a 7 chain structure with sequence from Buffalo rat. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:
NonStd Res:
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[PAWR_RAT] Pro-apoptopic protein capable of selectively inducing apoptosis in cancer cells, sensitizing the cells to diverse apoptotic stimuli and causing regression of tumors in animal models. Induces apoptosis in certain cancer cells by activation of the Fas prodeath pathway and coparallel inhibition of NF-kappa-B transcriptional activity. Inhibits the transcriptional activation and augments the transcriptional repression mediated by WT1. Down-regulates the anti-apoptotic protein BCL2 via its interaction with WT1. Seems also to be a transcriptional repressor by itself. May be directly involved in regulating the amyloid precursor protein (APP) cleavage activity of BACE1 (By similarity).

Publication Abstract from PubMed

Par-4 is a unique proapoptotic protein with the ability to induce apoptosis selectively in cancer cells. The X-ray crystal structure of the C-terminal domain of Par-4 (Par-4CC), which regulates its apoptotic function, was obtained by MAD phasing. Par-4 homodimerizes by forming a parallel coiled-coil structure. The N-terminal half of Par-4CC contains the homodimerization subdomain. This structure includes a nuclear export signal (Par-4NES) sequence, which is masked upon dimerization indicating a potential mechanism for nuclear localization. The heteromeric-interaction models specifically showed that charge interaction is an important factor in the stability of heteromers of the C-terminal leucine zipper subdomain of Par-4 (Par-4LZ). These heteromer models also displayed NES masking capacity and therefore the ability to influence intracellular localization.

Structural basis for the regulatory interactions of proapoptotic Par-4.,Tiruttani Subhramanyam UK, Kubicek J, Eidhoff UB, Labahn J Cell Death Differ. 2017 Sep;24(9):1540-1547. doi: 10.1038/cdd.2017.76. Epub 2017 , Jun 16. PMID:28622290^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Tiruttani Subhramanyam UK, Kubicek J, Eidhoff UB, Labahn J. Structural basis for the regulatory interactions of proapoptotic Par-4. Cell Death Differ. 2017 Sep;24(9):1540-1547. doi: 10.1038/cdd.2017.76. Epub 2017 , Jun 16. PMID:28622290 doi:http://dx.doi.org/10.1038/cdd.2017.76

1 Structural highlights
2 Function
3 Publication Abstract from PubMed
4 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/5fiy"

@@ Line 1: / Line 1: @@
 ==crystal structure of coiled coil domain of PAWR==
-<StructureSection load='5fiy' size='340' side='right' caption='[[5fiy]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
+<StructureSection load='5fiy' size='340' side='right'caption='[[5fiy]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[5fiy]] is a 7 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FIY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5FIY FirstGlance]. <br>
+<table><tr><td colspan='2'>[[5fiy]] is a 7 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FIY OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5FIY FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene></td></tr>
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene></td></tr>
 <tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5fiy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fiy OCA], [http://pdbe.org/5fiy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5fiy RCSB], [http://www.ebi.ac.uk/pdbsum/5fiy PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5fiy ProSAT]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5fiy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fiy OCA], [http://pdbe.org/5fiy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5fiy RCSB], [http://www.ebi.ac.uk/pdbsum/5fiy PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5fiy ProSAT]</span></td></tr>
 </table>
 == Function ==
@@ Line 24: / Line 24: @@
 </StructureSection>
 [[Category: Buffalo rat]]
+[[Category: Large Structures]]
 [[Category: Eidhoff, U B]]
 [[Category: Kubicek, J]]

5fiy

From Proteopedia

Revision as of 07:21, 6 May 2020

crystal structure of coiled coil domain of PAWR

Structural highlights

Function

Publication Abstract from PubMed

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

Views

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