Activin
From Proteopedia
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<StructureSection load='5hlz' size='340' side='right' caption='Human activin A (PDB code [[5hlz]])' scene=''> | <StructureSection load='5hlz' size='340' side='right' caption='Human activin A (PDB code [[5hlz]])' scene=''> | ||
== Function == | == Function == | ||
| - | '''Activin A''' or '''inhibitin β chain A''' (ActA) is a member of the TGF-β superfamily that inhibits the proliferation of breast cancer cells. Activin interacts with activin receptors to induce phosphorylation of intracellular signalling molecules which regulate the transcription of many genes in a cell- and tissue-specific manner | + | '''Activin A''' or '''inhibitin β chain A''' (ActA) is a member of the TGF-β superfamily that inhibits the proliferation of breast cancer cells. Activin interacts with activin receptors to induce phosphorylation of intracellular signalling molecules which regulate the transcription of many genes in a cell- and tissue-specific manner. |
== Relevance == | == Relevance == | ||
Revision as of 08:01, 7 May 2020
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3D structures of activin A
Updated on 07-May-2020
5hlz, 5hly - hActA - human
2arv - hActA mature domain residues 311-426
1nys, 1nyu, 1s4y - hActA mature domain + Acvr2B LBD
2b0u, 2arp, 2p6a - hActA mature domain + follistatin
3b4v - hActA mature domain + follistatin-like 3
References
- ↑ Hubner G, Brauchle M, Gregor M, Werner S. Activin A: a novel player and inflammatory marker in inflammatory bowel disease? Lab Invest. 1997 Oct;77(4):311-8. PMID:9354766
- ↑ Wang X, Fischer G, Hyvonen M. Structure and activation of pro-activin A. Nat Commun. 2016 Jul 4;7:12052. doi: 10.1038/ncomms12052. PMID:27373274 doi:http://dx.doi.org/10.1038/ncomms12052
