Deoxyuridine 5'-triphosphate nucleotidohydrolase
From Proteopedia
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== Function == | == Function == | ||
| - | '''Deoxyuridine 5’-triphosphate nucleotidohydrolase''' (DUTP) catalyzes the conversion of dUTP to dUMP and pyrophosphate (PPi). DUTP plays a key role in keeping significant amounts of dUTP from the DNA synthesis pathway. | + | '''Deoxyuridine 5’-triphosphate nucleotidohydrolase''' or '''Deoxyuridine triphosphatase'''(DUTP) catalyzes the conversion of dUTP to dUMP and pyrophosphate (PPi). DUTP plays a key role in keeping significant amounts of dUTP from the DNA synthesis pathway. |
Prokaryotic DUTP contains metal ion. <ref>PMID:18837522</ref> | Prokaryotic DUTP contains metal ion. <ref>PMID:18837522</ref> | ||
Revision as of 09:10, 7 May 2020
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References
- ↑ Vertessy BG, Toth J. Keeping uracil out of DNA: physiological role, structure and catalytic mechanism of dUTPases. Acc Chem Res. 2009 Jan 20;42(1):97-106. PMID:18837522 doi:10.1021/ar800114w
- ↑ Moroz OV, Harkiolaki M, Galperin MY, Vagin AA, Gonzalez-Pacanowska D, Wilson KS. The crystal structure of a complex of Campylobacter jejuni dUTPase with substrate analogue sheds light on the mechanism and suggests the "basic module" for dimeric d(C/U)TPases. J Mol Biol. 2004 Oct 1;342(5):1583-97. PMID:15364583 doi:10.1016/j.jmb.2004.07.050
