Nerve growth factor
From Proteopedia
(Difference between revisions)
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| - | <StructureSection load=' | + | <StructureSection load='1www' size='340' side='right' caption='Human NGF (pink, yellow) complex with glycosylated TrkA receptor (grey, green) (PDB code [[2ifg]])' scene=''> |
== Function == | == Function == | ||
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== Structural highlights == | == Structural highlights == | ||
| + | The 3D structure of the complex between human NGF and one of its receptors - TrkA - is shaped like a crab with the NGF homodimer serving as the crab's body. | ||
</StructureSection> | </StructureSection> | ||
Revision as of 10:02, 13 May 2020
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3D structures of nerve growth factor
Updated on 13-May-2020
4edk, 4edw, 5jz7 - hβ-NGF + antibody - human
2ifg, 1www - hβ-NGF + TrkA
1sg1 - hβ-NGF + neutrophin receptor
4zbn - hβ-NGF + DNA
6xuo - NGF - horse
1btg, 5lsd, 1sgf, 1bet - mNGF - mouse
4xpj, 4eax - mNGF + lipid
6ffy - mNGF + SorCS2
3ij2 - mNGF + TNFR
4ec7 - NGF + lipid - cobra
References
- ↑ Sofroniew MV, Howe CL, Mobley WC. Nerve growth factor signaling, neuroprotection, and neural repair. Annu Rev Neurosci. 2001;24:1217-81. doi: 10.1146/annurev.neuro.24.1.1217. PMID:11520933 doi:http://dx.doi.org/10.1146/annurev.neuro.24.1.1217
- ↑ Mufson EJ, Counts SE, Ginsberg SD, Mahady L, Perez SE, Massa SM, Longo FM, Ikonomovic MD. Nerve Growth Factor Pathobiology During the Progression of Alzheimer's Disease. Front Neurosci. 2019 Jul 1;13:533. doi: 10.3389/fnins.2019.00533. eCollection, 2019. PMID:31312116 doi:http://dx.doi.org/10.3389/fnins.2019.00533
