CD81
From Proteopedia
(Difference between revisions)
(New page: <StructureSection load='1stp' size='340' side='right' caption='Caption for this structure' scene=''> 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref...) |
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<StructureSection load='1stp' size='340' side='right' caption='Caption for this structure' scene=''> | <StructureSection load='1stp' size='340' side='right' caption='Caption for this structure' scene=''> | ||
| - | 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue. | ||
== Function == | == Function == | ||
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| + | CD81 is a cell-surface protein involved in a variety of biological responses like adhesion, morphology, activation, proliferation adn differentiation of of B- and T-cells<ref>PMID:9597125</ref>. CD81 belongs to the tetraspanin family - protein containing 4 transmembrane domains - which form microdomains in the cell surface with a variety of partner proteins. | ||
== Disease == | == Disease == | ||
== Relevance == | == Relevance == | ||
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| + | CD81 is widely expressed on the majority of tumor cells. Antibodies that target CD81 are a novel treatment against B-cell lymphoma<ref>PMID:31123084</ref>. CD81-defficient mice are impaired in their ability to suppress the anti-tumor immune response. | ||
== Structural highlights == | == Structural highlights == | ||
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==3D structures of CD81== | ==3D structures of CD81== | ||
| - | [[1g8q]] - hCD81 extracellular domain 113-202 - | + | [[5tcx]] - hCD81 (mutant) - human<br /> |
| + | [[1g8q]], [[1iv5]], [[5m3t]], [[5m3d]], [[5m4r]], [[5m33]], [[5m2c]], [[3x0e]], [[3x0f]] - hCD81 extracellular domain 113-202<br /> | ||
| + | [[6ejm]], [[6ek2]], [[6ejg]], [[5dfw]] - hCD81 extracellular domain + Scfv<br /> | ||
| + | [[5dfv]] - hCD81 extracellular domain + antibody<br /> | ||
[[3k0g]] - CD81 extracellular domain - green monkey<br /> | [[3k0g]] - CD81 extracellular domain - green monkey<br /> | ||
| + | [[6u9s]] - CD81 extracellular domain + antibody - mouse<br /> | ||
== References == | == References == | ||
<references/> | <references/> | ||
Revision as of 07:30, 17 May 2020
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3D structures of CD81
5tcx - hCD81 (mutant) - human
1g8q, 1iv5, 5m3t, 5m3d, 5m4r, 5m33, 5m2c, 3x0e, 3x0f - hCD81 extracellular domain 113-202
6ejm, 6ek2, 6ejg, 5dfw - hCD81 extracellular domain + Scfv
5dfv - hCD81 extracellular domain + antibody
3k0g - CD81 extracellular domain - green monkey
6u9s - CD81 extracellular domain + antibody - mouse
References
- ↑ Levy S, Todd SC, Maecker HT. CD81 (TAPA-1): a molecule involved in signal transduction and cell adhesion in the immune system. Annu Rev Immunol. 1998;16:89-109. doi: 10.1146/annurev.immunol.16.1.89. PMID:9597125 doi:http://dx.doi.org/10.1146/annurev.immunol.16.1.89
- ↑ Vences-Catalan F, Kuo CC, Rajapaksa R, Duault C, Andor N, Czerwinski DK, Levy R, Levy S. CD81 is a novel immunotherapeutic target for B cell lymphoma. J Exp Med. 2019 Jul 1;216(7):1497-1508. doi: 10.1084/jem.20190186. Epub 2019 May , 23. PMID:31123084 doi:http://dx.doi.org/10.1084/jem.20190186
