CD81

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CD81 is a cell-surface protein involved in a variety of biological responses like adhesion, morphology, activation, proliferation and differentiation of of B- and T-cells<ref>PMID:9597125</ref>. CD81 belongs to the tetraspanin family - protein containing 4 transmembrane domains - which form microdomains in the cell surface with a variety of partner proteins.
CD81 is a cell-surface protein involved in a variety of biological responses like adhesion, morphology, activation, proliferation and differentiation of of B- and T-cells<ref>PMID:9597125</ref>. CD81 belongs to the tetraspanin family - protein containing 4 transmembrane domains - which form microdomains in the cell surface with a variety of partner proteins.
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== Disease ==
 
== Relevance ==
== Relevance ==

Revision as of 08:23, 17 May 2020

Human CD81 (dark pink, cyan) complex with mouse antibody heavy chain (grey, yellow), light chain (green, light pink and glycerol (PDB code 6ejm)

Drag the structure with the mouse to rotate

3D structures of CD81

Updated on 17-May-2020

5tcx - hCD81 (mutant) - human
1g8q, 1iv5, 5m3t, 5m3d, 5m4r, 5m33, 5m2c, 3x0e, 3x0f - hCD81 extracellular domain 113-202
6ejm, 6ek2, 6ejg, 5dfw - hCD81 extracellular domain + Scfv
5dfv, 6u9s - hCD81 extracellular domain + antibody
3k0g - CD81 extracellular domain - green monkey

References

  1. ↑ Levy S, Todd SC, Maecker HT. CD81 (TAPA-1): a molecule involved in signal transduction and cell adhesion in the immune system. Annu Rev Immunol. 1998;16:89-109. doi: 10.1146/annurev.immunol.16.1.89. PMID:9597125 doi:http://dx.doi.org/10.1146/annurev.immunol.16.1.89
  2. ↑ Vences-Catalan F, Kuo CC, Rajapaksa R, Duault C, Andor N, Czerwinski DK, Levy R, Levy S. CD81 is a novel immunotherapeutic target for B cell lymphoma. J Exp Med. 2019 Jul 1;216(7):1497-1508. doi: 10.1084/jem.20190186. Epub 2019 May , 23. PMID:31123084 doi:http://dx.doi.org/10.1084/jem.20190186
  3. ↑ Susa KJ, Seegar TC, Blacklow SC, Kruse AC. A dynamic interaction between CD19 and the tetraspanin CD81 controls B cell co-receptor trafficking. Elife. 2020 Apr 27;9. pii: 52337. doi: 10.7554/eLife.52337. PMID:32338599 doi:http://dx.doi.org/10.7554/eLife.52337

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Michal Harel, Alexander Berchansky

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