Phospholipase A2 homolog
From Proteopedia
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<StructureSection load='1stp' size='340' side='right' caption='Caption for this structure' scene=''> | <StructureSection load='1stp' size='340' side='right' caption='Caption for this structure' scene=''> | ||
| - | 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue. | ||
== Function == | == Function == | ||
| - | '''Phospholipase A2 homolog''' or '''`Basic phospholipase A2 homolog''' | + | '''Phospholipase A2 homolog''' or '''`Basic phospholipase A2 homolog''' is a snake venom with phospholipase A2 (PLA2) sequence homology and structure homology which has almost no PLA2 activity, i.e., cleaving of fatty acids. The loss of PLA2 catalytic activity is due to the substition of the conserved Asp49 in the active site by Lys49 in the homolog<ref>PMID:19689412</ref>. |
== Disease == | == Disease == | ||
| + | |||
| + | The venom causes severe muscle necrosis. | ||
== Relevance == | == Relevance == | ||
Revision as of 07:25, 18 May 2020
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3D structures of phospholipase A2 homolog
Updated on 18-May-2020 {{#tree:id=OrganizedByTopic|openlevels=0|
- Phospholipase A2 homolog
- 1s8i, 1s8h - bbcMyotoxin - broad-banded copperhead
- 1s8g - bbcMyotoxin + fatty acid
- 4h0s - CTS-R6 - chinese green tree viper
- 3vbz, 3vc0 - taipoxin β subunit - Australian taipan
- 4nty, 4ntw - tcsMITTX + ASIC1 + neurotoxin - Texas coral snake
- 4ntx - tcsMITTX + ASIC1 + neurotoxin + amiloride
- 2ph4 - Zhaoermiatoxin - Zhaoermia mangshanensis
- 1mc2 - Acutohaemolysin - chinese moccasin
- 1s8i, 1s8h - bbcMyotoxin - broad-banded copperhead
- Phospholipase A2 homolog 1
- Phospholipase A2 homolog 2
- 6pwh - lhvMyotoxin II
- 2aoz - Myotoxin II - Atropoides nummifer
- 6b84, 4kf3 - BmMyotoxin II
- 6b81 - BmMyotoxin II + caprylic acid
- 6b83 - BmMyotoxin II + caproic acid
- 6mqd - BmMyotoxin II + rosmarinic acid
- 1xxs - BmMyotoxin II + stearic acid
- 6b80 - BmMyotoxin II + myristic acid
- 6mqf - BmMyotoxin II + acetylsalicylic acid
- 4yv5 - BmMyotoxin II + suramin
- 1clp - BaMyotoxin II - Bothrops asper
- 1y4l - BaMyotoxin II + suramin
- 5vfh, 1pa0 - nlBnsp-7 - neuwid's lancehead
- 5vfn - nlBnsp-7 + cinnamic acid
- 5vfm - nlBnsp-7 + coumaric acid
- 5vfj - nlBnsp-7 + caffeic acid
- 1pc9 - nlBnsp-6
- 3qll - plhPiratoxin II
- 3god - Godmt II - Cerrophidion godmani
- 6pwh - lhvMyotoxin II
- Phospholipase A2 homolog bothropstoxin
- Phospholipase A2 homolog ammodytin-l
- 3dih - Adl - western sand viper
- 3dih - Adl - western sand viper
}}
References
- ↑ Lomonte B, Angulo Y, Sasa M, Gutierrez JM. The phospholipase A2 homologues of snake venoms: biological activities and their possible adaptive roles. Protein Pept Lett. 2009;16(8):860-76. doi: 10.2174/092986609788923356. PMID:19689412 doi:http://dx.doi.org/10.2174/092986609788923356
