User:Andre Wu Le Chun/Sandbox 1
From Proteopedia
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== Structural highlights == | == Structural highlights == | ||
| - | 6vsb is a trimeric glycoprotein with 3 chains in it's structure. There are two subunits which are | + | 6vsb is a trimeric glycoprotein with 3 chains in it's structure. There are two subunits which are fundamental for the virus entry in the cell: the S1 subunit and the S2 subunit. |
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== Function == | == Function == | ||
| - | The spike glycoprotein reconizes the | + | The spike glycoprotein reconizes the hosts cell's angiotensin-converting enzime 2 (ACE2) receptor and binds itself on it, allowing the fusion of viral and cellular membrane. |
== Disease == | == Disease == | ||
| - | 6vsb is a protein related to the | + | 6vsb is a protein related to the virus entry in the cell. Therefore, has an enormous role on the new coronavirus pandemic, in 2020. |
== Relevance == | == Relevance == | ||
| - | Potential target for antibodies. Development of vacines based on the structure of the protein and it's biding mechanisms. | + | Potential target for antibodies. Development of vacines based on the structure of the protein and on it's recognition/biding mechanisms. |
== Interaction with angiotensin-converting enzime 2 receptor == | == Interaction with angiotensin-converting enzime 2 receptor == | ||
| - | + | The interaction between the 2019-nCov and the host cell begins with the recognition of the ACE2 receptor. Then, the S1 subunit moves, modifying the protein's conformation in way that determinants for the virus-cell binding. Due to the conformational movements, the protein structure assumes a conformation which is suitable for binding with the ACE2 receptor. At that instance, the spike protein is found in a "up" conformation, hence the protein's name. | |
This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes. | This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes. | ||
Revision as of 12:19, 18 May 2020
6vsb
Prefusion 2019-nCoV spike glycoprotein with a single receptor-binding domain up
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References
- ↑ Hanson, R. M., Prilusky, J., Renjian, Z., Nakane, T. and Sussman, J. L. (2013), JSmol and the Next-Generation Web-Based Representation of 3D Molecular Structure as Applied to Proteopedia. Isr. J. Chem., 53:207-216. doi:http://dx.doi.org/10.1002/ijch.201300024
- ↑ Herraez A. Biomolecules in the computer: Jmol to the rescue. Biochem Mol Biol Educ. 2006 Jul;34(4):255-61. doi: 10.1002/bmb.2006.494034042644. PMID:21638687 doi:10.1002/bmb.2006.494034042644
