Increased sodium tolerance protein
From Proteopedia
(Difference between revisions)
(New page: <StructureSection load='1stp' size='340' side='right' caption='Caption for this structure' scene=''> 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref...) |
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<StructureSection load='1stp' size='340' side='right' caption='Caption for this structure' scene=''> | <StructureSection load='1stp' size='340' side='right' caption='Caption for this structure' scene=''> | ||
| - | 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue. | ||
== Function == | == Function == | ||
| - | '''Increased sodium tolerance protein''' | + | '''Increased sodium tolerance protein 1''' (Ist1) is a family member of the transport-III (ESCRT-III) forming high-order helical structures with CHMP1B which are required in remodeling membranes during abscission<ref>PMID:19525971</ref>.<br /> |
| + | '''Increased sodium tolerance protein 3''' (Ist3) or '''U2 snRNP component IST3''' (Ist3) is part of the spliceosome which is involved in transcription and pre-mRNA splicing. Ist3 interacts with human elongation factors and strongly stimulates polymerase elongation<ref>PMID:11780068</ref>. | ||
== Disease == | == Disease == | ||
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| + | Somatic mutations in Ist3 have been found in various malignancies like breast cancer, pancreatuc cancer, uveal melanoma and others<ref>PMID:27991914</ref>. | ||
== Relevance == | == Relevance == | ||
Revision as of 07:19, 19 May 2020
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3D structures of increased sodium tolerance protein
Updated on 19-May-2020
References
- ↑ Bajorek M, Schubert HL, McCullough J, Langelier C, Eckert DM, Stubblefield WM, Uter NT, Myszka DG, Hill CP, Sundquist WI. Structural basis for ESCRT-III protein autoinhibition. Nat Struct Mol Biol. 2009 Jul;16(7):754-62. Epub 2009 Jun 14. PMID:19525971 doi:10.1038/nsmb.1621
- ↑ Fong YW, Zhou Q. Stimulatory effect of splicing factors on transcriptional elongation. Nature. 2001 Dec 20-27;414(6866):929-33. PMID:11780068 doi:http://dx.doi.org/10.1038/414929a
- ↑ Tanikawa M, Sanjiv K, Helleday T, Herr P, Mortusewicz O. The spliceosome U2 snRNP factors promote genome stability through distinct mechanisms; transcription of repair factors and R-loop processing. Oncogenesis. 2016 Dec 19;5(12):e280. doi: 10.1038/oncsis.2016.70. PMID:27991914 doi:http://dx.doi.org/10.1038/oncsis.2016.70
