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6tsx

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Revision as of 06:08, 20 May 2020

Crystal structure of horse L ferritin (HoLf) Fe(III)-loaded for 30 minutes

Structural highlights

6tsx is a 1 chain structure with sequence from Equus caballus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:	, , ,
NonStd Res:
Related:	6tsj, 6tsa, 6tsf, 6tr9, 6ts0, 6ts1, 6trz, 6tss
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[FRIL_HORSE] Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity).

Publication Abstract from PubMed

X-ray structures of homopolymeric human L-ferritin and horse spleen ferritin were solved by freezing protein crystals at different time intervals after exposure to a ferric salt and revealed the growth of an octa-nuclear iron cluster on the inner surface of the protein cage with a key role played by some glutamate residues. An atomic resolution view of how the cluster formation develops starting from a (mu 3 -oxo)tris[(mu 2 -glutamato-kappaO:kappaO')](glutamato-kappaO)(diaquo)triiron(III) seed is provided. The results support the idea that iron biomineralization in ferritin is a process initiating at the level of the protein surface, capable of contributing coordination bonds and electrostatic guidance.

Iron biomineral growth from the initial nucleation seed in L-ferritin.,Ciambellotti S, Pozzi C, Mangani S, Turano P Chemistry. 2020 Feb 6. doi: 10.1002/chem.202000064. PMID:32027764^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Ciambellotti S, Pozzi C, Mangani S, Turano P. Iron biomineral growth from the initial nucleation seed in L-ferritin. Chemistry. 2020 Feb 6. doi: 10.1002/chem.202000064. PMID:32027764 doi:http://dx.doi.org/10.1002/chem.202000064

1 Structural highlights
2 Function
3 Publication Abstract from PubMed
4 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/6tsx"

@@ Line 3: / Line 3: @@
 <StructureSection load='6tsx' size='340' side='right'caption='[[6tsx]], [[Resolution|resolution]] 2.02&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[6tsx]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Equus_caballus Equus caballus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6TSX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6TSX FirstGlance]. <br>
+<table><tr><td colspan='2'>[[6tsx]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Equus_caballus Equus caballus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6TSX OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6TSX FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=O:OXYGEN+ATOM'>O</scene></td></tr>
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=O:OXYGEN+ATOM'>O</scene></td></tr>
 <tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CME:S,S-(2-HYDROXYETHYL)THIOCYSTEINE'>CME</scene></td></tr>
 <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[6tsj|6tsj]], [[6tsa|6tsa]], [[6tsf|6tsf]], [[6tr9|6tr9]], [[6ts0|6ts0]], [[6ts1|6ts1]], [[6trz|6trz]], [[6tss|6tss]]</td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6tsx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6tsx OCA], [http://pdbe.org/6tsx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6tsx RCSB], [http://www.ebi.ac.uk/pdbsum/6tsx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6tsx ProSAT]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6tsx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6tsx OCA], [http://pdbe.org/6tsx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6tsx RCSB], [http://www.ebi.ac.uk/pdbsum/6tsx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6tsx ProSAT]</span></td></tr>
 </table>
 == Function ==

6tsx

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Revision as of 06:08, 20 May 2020

Crystal structure of horse L ferritin (HoLf) Fe(III)-loaded for 30 minutes

Structural highlights

Function

Publication Abstract from PubMed

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

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