6yto
From Proteopedia
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==Cryo-EM structure of a dimer of decameric human CALHM4 in the presence of Ca2+== | ==Cryo-EM structure of a dimer of decameric human CALHM4 in the presence of Ca2+== | ||
| - | <StructureSection load='6yto' size='340' side='right'caption='[[6yto]]' scene=''> | + | <StructureSection load='6yto' size='340' side='right'caption='[[6yto]], [[Resolution|resolution]] 4.24Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6YTO OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6YTO FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[6yto]] is a 20 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6YTO OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6YTO FirstGlance]. <br> |
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6yto FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6yto OCA], [http://pdbe.org/6yto PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6yto RCSB], [http://www.ebi.ac.uk/pdbsum/6yto PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6yto ProSAT]</span></td></tr> | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6yto FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6yto OCA], [http://pdbe.org/6yto PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6yto RCSB], [http://www.ebi.ac.uk/pdbsum/6yto PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6yto ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/CAHM4_HUMAN CAHM4_HUMAN]] Pore-forming subunit of a voltage-gated ion channel.[UniProtKB:Q8IU99] | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | The transport of substances across the placenta is essential for the development of the fetus. Here, we were interested in the role of channels of the calcium homeostasis modulator (CALHM) family in the human placenta. By transcript analysis, we found the paralogs CALHM2, 4, and 6 to be highly expressed in this organ and upregulated during trophoblast differentiation. Based on electrophysiology, we found that activation of these paralogs differs from the voltage- and calcium-gated channel CALHM1. Cryo-EM structures of CALHM4 display decameric and undecameric assemblies with large cylindrical pore, while in CALHM6 a conformational change has converted the pore shape into a conus that narrows at the intracellular side, thus describing distinct functional states of the channel. The pore geometry alters the distribution of lipids, which occupy the cylindrical pore of CALHM4 in a bilayer-like arrangement whereas they have redistributed in the conical pore of CALHM6 with potential functional consequences. | ||
| + | |||
| + | Cryo-EM structures and functional properties of CALHM channels of the human placenta.,Drozdzyk K, Sawicka M, Bahamonde-Santos MI, Jonas Z, Deneka D, Albrecht C, Dutzler R Elife. 2020 May 6;9. pii: 55853. doi: 10.7554/eLife.55853. PMID:32374262<ref>PMID:32374262</ref> | ||
| + | |||
| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 6yto" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Drozdzyk K]] | + | [[Category: Drozdzyk, K]] |
| - | [[Category: Dutzler R]] | + | [[Category: Dutzler, R]] |
| - | [[Category: Sawicka M]] | + | [[Category: Sawicka, M]] |
| + | [[Category: Calcium homeostasis modulator]] | ||
| + | [[Category: Ion channel]] | ||
| + | [[Category: Membrane protein]] | ||
| + | [[Category: Placenta]] | ||
Revision as of 06:16, 20 May 2020
Cryo-EM structure of a dimer of decameric human CALHM4 in the presence of Ca2+
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