2n7r

From Proteopedia

(Difference between revisions)

Revision as of 06:31, 20 May 2020

Structure of the transmembrane domain of human nicastrin in DPC micelles

Structural highlights

2n7r is a 1 chain structure with sequence from Human. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
Related:	2n7q
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Disease

[NICA_HUMAN] Hidradenitis suppurativa. The disease is caused by mutations affecting the gene represented in this entry.

Function

[NICA_HUMAN] Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). It probably represents a stabilizing cofactor required for the assembly of the gamma-secretase complex.

Publication Abstract from PubMed

Nicastrin is the largest component of gamma-secretase that is an intramembrane protease important in the development of Alzheimer's disease. Nicastrin contains a large extracellular domain, a single transmembrane (TM) domain, and a short C-terminus. Its TM domain is important for the gamma-secretase complex formation. Here we report nuclear magnetic resonance (NMR) studies of the TM and C-terminal regions of human nicastrin in both sodium dodecyl sulfate (SDS) and dodecylphosphocholine (DPC) micelles. Structural study and dynamic analysis reveal that the TM domain is largely helical and stable under both SDS and DPC micelles with its N-terminal region undergoing intermediate time scale motion. The TM helix contains a hydrophilic patch that is important for TM-TM interactions. The short C-terminus is not structured in solution and a region formed by residues V697-A702 interacts with the membrane, suggesting that these residues may play a role in the gamma-secretase complex formation. Our study provides structural insight into the function of the nicastrin TM domain and the C-terminus in gamma-secretase complex.

Structure of the transmembrane domain of human nicastrin-a component of gamma-secretase.,Li Y, Liew LS, Li Q, Kang C Sci Rep. 2016 Jan 18;6:19522. doi: 10.1038/srep19522. PMID:26776682^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Li Y, Liew LS, Li Q, Kang C. Structure of the transmembrane domain of human nicastrin-a component of gamma-secretase. Sci Rep. 2016 Jan 18;6:19522. doi: 10.1038/srep19522. PMID:26776682 doi:http://dx.doi.org/10.1038/srep19522

1 Structural highlights
2 Disease
3 Function
4 Publication Abstract from PubMed
5 See Also
6 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2n7r"

@@ Line 1: / Line 1: @@
 ==Structure of the transmembrane domain of human nicastrin in DPC micelles==
-<StructureSection load='2n7r' size='340' side='right' caption='[[2n7r]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
+<StructureSection load='2n7r' size='340' side='right'caption='[[2n7r]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[2n7r]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2N7R OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2N7R FirstGlance]. <br>
+<table><tr><td colspan='2'>[[2n7r]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2N7R OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2N7R FirstGlance]. <br>
 </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2n7q|2n7q]]</td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2n7r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2n7r OCA], [http://pdbe.org/2n7r PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2n7r RCSB], [http://www.ebi.ac.uk/pdbsum/2n7r PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2n7r ProSAT]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2n7r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2n7r OCA], [http://pdbe.org/2n7r PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2n7r RCSB], [http://www.ebi.ac.uk/pdbsum/2n7r PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2n7r ProSAT]</span></td></tr>
 </table>
 == Disease ==
@@ Line 20: / Line 20: @@
 </div>
 <div class="pdbe-citations 2n7r" style="background-color:#fffaf0;"></div>
+==See Also==
+*[[Gamma secretase complex|Gamma secretase complex]]
 == References ==
 <references/>
@@ Line 25: / Line 28: @@
 </StructureSection>
 [[Category: Human]]
+[[Category: Large Structures]]
 [[Category: Kang, C]]
 [[Category: Li, Q]]

2n7r

From Proteopedia

Revision as of 06:31, 20 May 2020

Structure of the transmembrane domain of human nicastrin in DPC micelles

Structural highlights

Disease

Function

Publication Abstract from PubMed

See Also

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

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