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2nou

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Revision as of 06:33, 20 May 2020

Membrane induced structure of Scyliorhinin I: A Dual NK1/NK2 agonist

Structural highlights

2nou is a 1 chain structure. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
Related:	2nor
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[TKN1_SCYCA] Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles.

Publication Abstract from PubMed

Scyliorhinin I, a linear decapeptide, is the only known tachykinin that shows high affinity for both NK-1 and NK-2 binding sites and low affinity for NK-3 binding sites. As a first step to understand the structure-activity relationship, we report the membrane-induced structure of scyliorhinin I with the aid of circular dichroism and 2D-(1)H NMR spectroscopy. Sequence specific resonance assignments of protons have been made from correlation spectroscopy (TOCSY, DQF-COSY) and NOESY spectroscopy. The interproton distance constraints and dihedral angle constraints have been utilized to generate a family of structures using DYANA. The superimposition of 20 final structures has been reported with backbone pairwise root mean-square deviation of 0.38 +/- 0.19 A. The results show that scyliorhinin I exists in a random coil state in aqueous environments, whereas helical conformation is induced toward the C-terminal region of the peptide (D4-M10) in the presence of dodecyl phosphocholine micelles. Analysis of NMR data is suggestive of the presence of a 3(10)-helix that is in equilibrium with an alpha-helix in this region from residue 4 to 10. An extended highly flexible N-terminus of scyliorhinin I displays some degree of order and a possible turn structure. Observed conformational features have been compared with respect to that of substance P and neurokinin A, which are endogenous agonists of NK-1 and NK-2 receptors, respectively.

Membrane-Induced Structure of Scyliorhinin I: A Dual NK1/NK2 Agonist.,Dike A, Cowsik SM Biophys J. 2005 May;88(5):3592-600. Epub 2005 Feb 24. PMID:15731392^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Dike A, Cowsik SM. Membrane-Induced Structure of Scyliorhinin I: A Dual NK1/NK2 Agonist. Biophys J. 2005 May;88(5):3592-600. Epub 2005 Feb 24. PMID:15731392 doi:biophysj.104.053231

1 Structural highlights
2 Function
3 Publication Abstract from PubMed
4 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2nou"

@@ Line 1: / Line 1: @@
 ==Membrane induced structure of Scyliorhinin I: A Dual NK1/NK2 agonist==
-<StructureSection load='2nou' size='340' side='right' caption='[[2nou]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
+<StructureSection load='2nou' size='340' side='right'caption='[[2nou]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[2nou]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NOU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2NOU FirstGlance]. <br>
+<table><tr><td colspan='2'>[[2nou]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NOU OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2NOU FirstGlance]. <br>
 </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2nor|2nor]]</td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2nou FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2nou OCA], [http://pdbe.org/2nou PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2nou RCSB], [http://www.ebi.ac.uk/pdbsum/2nou PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2nou ProSAT]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2nou FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2nou OCA], [http://pdbe.org/2nou PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2nou RCSB], [http://www.ebi.ac.uk/pdbsum/2nou PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2nou ProSAT]</span></td></tr>
 </table>
 == Function ==
@@ Line 22: / Line 22: @@
 __TOC__
 </StructureSection>
+[[Category: Large Structures]]
 [[Category: Cowsik, S M]]
 [[Category: Dike, A]]

2nou

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Revision as of 06:33, 20 May 2020

Membrane induced structure of Scyliorhinin I: A Dual NK1/NK2 agonist

Structural highlights

Function

Publication Abstract from PubMed

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

Views

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