5gs5

Structural highlights

Function

[STING_RAT] Facilitator of innate immune signaling that acts as a sensor of cytosolic DNA from bacteria and viruses and promotes the production of type I interferon (IFN-alpha and IFN-beta). Innate immune response is triggered in response to non-CpG double-stranded DNA from viruses and bacteria delivered to the cytoplasm. Acts by recognizing and binding cyclic di-GMP (c-di-GMP), a second messenger produced by bacteria, and cyclic GMP-AMP (cGAMP), a messenger produced in response to DNA virus in the cytosol: upon binding of c-di-GMP or cGAMP, autoinhibition is alleviated and TMEM173/STING is able to activate both NF-kappa-B and IRF3 transcription pathways to induce expression of type I interferon and exert a potent anti-viral state (PubMed:26669264). May be involved in translocon function, the translocon possibly being able to influence the induction of type I interferons. May be involved in transduction of apoptotic signals via its association with the major histocompatibility complex class II (MHC-II). Mediates death signaling via activation of the extracellular signal-regulated kinase (ERK) pathway (By similarity). Exhibits 2',3' phosphodiester linkage-specific ligand recognition. Can bind both 2'-3' linked cGAMP and 3'-3' linked cGAMP; the precise binding affinity may be species-specific and rat TMEM173/STING is preferentially activated by 3'-3' linked cGAMP (PubMed:26669264).[UniProtKB:Q86WV6]^[1]

References

1. ↑ Zhang H, Han MJ, Tao J, Ye ZY, Du XX, Deng MJ, Zhang XY, Li LF, Jiang ZF, Su XD. Rat and human STINGs profile similarly towards anticancer/antiviral compounds. Sci Rep. 2015 Dec 16;5:18035. doi: 10.1038/srep18035. PMID:26669264 doi:http://dx.doi.org/10.1038/srep18035
2. ↑ Zhang H, Han MJ, Tao J, Ye ZY, Du XX, Deng MJ, Zhang XY, Li LF, Jiang ZF, Su XD. Rat and human STINGs profile similarly towards anticancer/antiviral compounds. Sci Rep. 2015 Dec 16;5:18035. doi: 10.1038/srep18035. PMID:26669264 doi:http://dx.doi.org/10.1038/srep18035