1bd7

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[[Image:1bd7.gif|left|200px]]
[[Image:1bd7.gif|left|200px]]
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{{Structure
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The line below this paragraph, containing "STRUCTURE_1bd7", creates the "Structure Box" on the page.
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{{STRUCTURE_1bd7| PDB=1bd7 | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1bd7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bd7 OCA], [http://www.ebi.ac.uk/pdbsum/1bd7 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1bd7 RCSB]</span>
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'''CIRCULARLY PERMUTED BB2-CRYSTALLIN'''
'''CIRCULARLY PERMUTED BB2-CRYSTALLIN'''
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[[Category: Slingsby, C.]]
[[Category: Slingsby, C.]]
[[Category: Wright, G.]]
[[Category: Wright, G.]]
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[[Category: beta-crystallin b]]
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[[Category: Beta-crystallin b]]
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[[Category: eye-lens protein]]
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[[Category: Eye-lens protein]]
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[[Category: multigene family]]
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[[Category: Multigene family]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 11:21:44 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 18:58:43 2008''
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Revision as of 08:21, 2 May 2008

Template:STRUCTURE 1bd7

CIRCULARLY PERMUTED BB2-CRYSTALLIN


Overview

The betagamma-crystallins form a superfamily of eye lens proteins comprised of multiple Greek motifs that are symmetrically organized into domains and higher assemblies. In the betaB2-crystallin dimer each polypeptide folds into two similar domains that are related to monomeric gamma-crystallin by domain swapping. The crystal structure of the circularly permuted two-domain betaB2 polypeptide shows that permutation converts intermolecular domain pairing into intramolecular pairing. However, the dimeric permuted protein is, in fact, half a native tetramer. This result shows how the sequential order of domains in multi-domain proteins can affect quaternary domain assembly.

About this Structure

1BD7 is a Single protein structure of sequence from Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

Circular permutation of betaB2-crystallin changes the hierarchy of domain assembly., Wright G, Basak AK, Wieligmann K, Mayr EM, Slingsby C, Protein Sci. 1998 Jun;7(6):1280-5. PMID:9655330 Page seeded by OCA on Fri May 2 11:21:44 2008

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