1bfe
From Proteopedia
| Line 1: | Line 1: | ||
[[Image:1bfe.gif|left|200px]] | [[Image:1bfe.gif|left|200px]] | ||
| - | + | <!-- | |
| - | + | The line below this paragraph, containing "STRUCTURE_1bfe", creates the "Structure Box" on the page. | |
| - | + | You may change the PDB parameter (which sets the PDB file loaded into the applet) | |
| - | | | + | or the SCENE parameter (which sets the initial scene displayed when the page is loaded), |
| - | | | + | or leave the SCENE parameter empty for the default display. |
| - | + | --> | |
| - | + | {{STRUCTURE_1bfe| PDB=1bfe | SCENE= }} | |
| - | + | ||
| - | + | ||
| - | }} | + | |
'''THE THIRD PDZ DOMAIN FROM THE SYNAPTIC PROTEIN PSD-95''' | '''THE THIRD PDZ DOMAIN FROM THE SYNAPTIC PROTEIN PSD-95''' | ||
| Line 31: | Line 28: | ||
[[Category: Mackinnon, R.]] | [[Category: Mackinnon, R.]] | ||
[[Category: Sheng, M.]] | [[Category: Sheng, M.]] | ||
| - | [[Category: | + | [[Category: Peptide recognition]] |
| - | [[Category: | + | [[Category: Protein localization]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 11:26:37 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 08:26, 2 May 2008
THE THIRD PDZ DOMAIN FROM THE SYNAPTIC PROTEIN PSD-95
Overview
Modular PDZ domains, found in many cell junction-associated proteins, mediate the clustering of membrane ion channels by binding to their C-terminus. The X-ray crystallographic structures of the third PDZ domain from the synaptic protein PSD-95 in complex with and in the absence of its peptide ligand have been determined at 1.8 angstroms and 2.3 angstroms resolution, respectively. The structures reveal that a four-residue C-terminal stretch (X-Thr/Ser-X-Val-COO(-)) engages the PDZ domain through antiparallel main chain interactions with a beta sheet of the domain. Recognition of the terminal carboxylate group of the peptide is conferred by a cradle of main chain amides provided by a Gly-Leu-Gly-Phe loop as well as by an arginine side chain. Specific side chain interactions and a prominent hydrophobic pocket explain the selective recognition of the C-terminal consensus sequence.
About this Structure
1BFE is a Single protein structure of sequence from Rattus norvegicus. Full crystallographic information is available from OCA.
Reference
Crystal structures of a complexed and peptide-free membrane protein-binding domain: molecular basis of peptide recognition by PDZ., Doyle DA, Lee A, Lewis J, Kim E, Sheng M, MacKinnon R, Cell. 1996 Jun 28;85(7):1067-76. PMID:8674113 Page seeded by OCA on Fri May 2 11:26:37 2008
