1bfw

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[[Image:1bfw.gif|left|200px]]
[[Image:1bfw.gif|left|200px]]
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{{Structure
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|PDB= 1bfw |SIZE=350|CAPTION= <scene name='initialview01'>1bfw</scene>
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The line below this paragraph, containing "STRUCTURE_1bfw", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=DAL:D-ALANINE'>DAL</scene>, <scene name='pdbligand=DAR:D-ARGININE'>DAR</scene>, <scene name='pdbligand=DAS:D-ASPARTIC+ACID'>DAS</scene>, <scene name='pdbligand=DGN:D-GLUTAMINE'>DGN</scene>, <scene name='pdbligand=DLE:D-LEUCINE'>DLE</scene>, <scene name='pdbligand=DPN:D-PHENYLALANINE'>DPN</scene>, <scene name='pdbligand=DPR:D-PROLINE'>DPR</scene>, <scene name='pdbligand=DSN:D-SERINE'>DSN</scene>, <scene name='pdbligand=DVA:D-VALINE'>DVA</scene>, <scene name='pdbligand=LML:ISOBUTYL+MALONIC+ACID'>LML</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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or leave the SCENE parameter empty for the default display.
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|GENE=
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|DOMAIN=
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{{STRUCTURE_1bfw| PDB=1bfw | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1bfw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bfw OCA], [http://www.ebi.ac.uk/pdbsum/1bfw PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1bfw RCSB]</span>
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}}
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'''RETRO-INVERSO ANALOGUE OF THE G-H LOOP OF VP1 IN FOOT-AND-MOUTH-DISEASE (FMD) VIRUS, NMR, 10 STRUCTURES'''
'''RETRO-INVERSO ANALOGUE OF THE G-H LOOP OF VP1 IN FOOT-AND-MOUTH-DISEASE (FMD) VIRUS, NMR, 10 STRUCTURES'''
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==About this Structure==
==About this Structure==
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1BFW is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BFW OCA].
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Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BFW OCA].
==Reference==
==Reference==
Solution structure of a retro-inverso peptide analogue mimicking the foot-and-mouth disease virus major antigenic site. Structural basis for its antigenic cross-reactivity with the parent peptide., Petit MC, Benkirane N, Guichard G, Du AP, Marraud M, Cung MT, Briand JP, Muller S, J Biol Chem. 1999 Feb 5;274(6):3686-92. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9920919 9920919]
Solution structure of a retro-inverso peptide analogue mimicking the foot-and-mouth disease virus major antigenic site. Structural basis for its antigenic cross-reactivity with the parent peptide., Petit MC, Benkirane N, Guichard G, Du AP, Marraud M, Cung MT, Briand JP, Muller S, J Biol Chem. 1999 Feb 5;274(6):3686-92. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9920919 9920919]
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[[Category: Protein complex]]
 
[[Category: Benkirane, N.]]
[[Category: Benkirane, N.]]
[[Category: Briand, J P.]]
[[Category: Briand, J P.]]
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[[Category: Muller, S.]]
[[Category: Muller, S.]]
[[Category: Petit, M C.]]
[[Category: Petit, M C.]]
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[[Category: antigen]]
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[[Category: Antigen]]
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[[Category: capsid]]
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[[Category: Capsid]]
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[[Category: fmdv]]
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[[Category: Fmdv]]
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[[Category: peptidomimetic]]
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[[Category: Peptidomimetic]]
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[[Category: retro-inverso]]
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[[Category: Retro-inverso]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 11:27:36 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 19:00:03 2008''
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Revision as of 08:27, 2 May 2008

Image:1bfw.gif

Template:STRUCTURE 1bfw

RETRO-INVERSO ANALOGUE OF THE G-H LOOP OF VP1 IN FOOT-AND-MOUTH-DISEASE (FMD) VIRUS, NMR, 10 STRUCTURES


Overview

The antigenic activity of a 19-mer peptide corresponding to the major antigenic region of foot-and-mouth disease virus and its retro-enantiomeric analogue was found to be completely abolished when they were tested in a biosensor system in trifluoroethanol. This suggests that the folding pattern, which is alpha-helix in trifluoroethanol (confirmed by CD measurement), does not correspond to the biologically relevant conformation(s) recognized by antibodies. The NMR structures of both peptides were thus determined in aqueous solution. These studies showed that the two peptides exhibit similar folding features, particularly in their C termini. This may explain in part the cross-reactive properties of the two peptides in aqueous solution. However, the retro-inverso analogue appears to be more rigid than the parent peptide and contains five atypical beta-turns. This feature may explain why retro-inverso foot-and-mouth disease virus peptides are often better recognized than the parent peptide by anti-virion antibodies.

About this Structure

Full crystallographic information is available from OCA.

Reference

Solution structure of a retro-inverso peptide analogue mimicking the foot-and-mouth disease virus major antigenic site. Structural basis for its antigenic cross-reactivity with the parent peptide., Petit MC, Benkirane N, Guichard G, Du AP, Marraud M, Cung MT, Briand JP, Muller S, J Biol Chem. 1999 Feb 5;274(6):3686-92. PMID:9920919 Page seeded by OCA on Fri May 2 11:27:36 2008

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