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5if7
From Proteopedia
(Difference between revisions)
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==Crystal structure of polymerase acid protein (PA) from Influenza A virus, WILSON-SMITH/1933 (H1N1) bound to fragment hit EBSI-279 N-[(4-chlorophenyl)methyl]-1-methyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine== | ==Crystal structure of polymerase acid protein (PA) from Influenza A virus, WILSON-SMITH/1933 (H1N1) bound to fragment hit EBSI-279 N-[(4-chlorophenyl)methyl]-1-methyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine== | ||
| - | <StructureSection load='5if7' size='340' side='right' caption='[[5if7]], [[Resolution|resolution]] 2.65Å' scene=''> | + | <StructureSection load='5if7' size='340' side='right'caption='[[5if7]], [[Resolution|resolution]] 2.65Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[5if7]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IF7 OCA]. For a <b>guided tour on the structure components</b> use [http:// | + | <table><tr><td colspan='2'>[[5if7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/I33a0 I33a0]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IF7 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5IF7 FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=6AY:N-[(4-CHLOROPHENYL)METHYL]-1-METHYL-1H-PYRAZOLO[3,4-D]PYRIMIDIN-4-AMINE'>6AY</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=6AY:N-[(4-CHLOROPHENYL)METHYL]-1-METHYL-1H-PYRAZOLO[3,4-D]PYRIMIDIN-4-AMINE'>6AY</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene></td></tr> |
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4iuj|4iuj]], [[5ieq|5ieq]], [[5if2|5if2]], [[5if5|5if5]], [[5if8|5if8]], [[5ifb|5ifb]], [[5ifc|5ifc]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4iuj|4iuj]], [[5ieq|5ieq]], [[5if2|5if2]], [[5if5|5if5]], [[5if8|5if8]], [[5ifb|5ifb]], [[5ifc|5ifc]]</td></tr> | ||
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http:// | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=381518 I33A0])</td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5if7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5if7 OCA], [http://pdbe.org/5if7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5if7 RCSB], [http://www.ebi.ac.uk/pdbsum/5if7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5if7 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[[http://www.uniprot.org/uniprot/PA_I33A0 PA_I33A0]] Implicated in endonuclease cleavage of capped RNA primers. Displays an elongation factor activity in viral RNA synthesis. Dispensable for viral transcription, but not replication. | [[http://www.uniprot.org/uniprot/PA_I33A0 PA_I33A0]] Implicated in endonuclease cleavage of capped RNA primers. Displays an elongation factor activity in viral RNA synthesis. Dispensable for viral transcription, but not replication. | ||
| + | |||
| + | ==See Also== | ||
| + | *[[RNA polymerase 3D structures|RNA polymerase 3D structures]] | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: I33a0]] | ||
| + | [[Category: Large Structures]] | ||
[[Category: Structural genomic]] | [[Category: Structural genomic]] | ||
[[Category: Flu]] | [[Category: Flu]] | ||
Revision as of 07:16, 3 June 2020
Crystal structure of polymerase acid protein (PA) from Influenza A virus, WILSON-SMITH/1933 (H1N1) bound to fragment hit EBSI-279 N-[(4-chlorophenyl)methyl]-1-methyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine
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Categories: I33a0 | Large Structures | Structural genomic | Flu | Fragment screening | Niaid | Ssgcid | Std nmr | Viral protein
