1bg7
From Proteopedia
| Line 1: | Line 1: | ||
[[Image:1bg7.gif|left|200px]] | [[Image:1bg7.gif|left|200px]] | ||
| - | + | <!-- | |
| - | + | The line below this paragraph, containing "STRUCTURE_1bg7", creates the "Structure Box" on the page. | |
| - | + | You may change the PDB parameter (which sets the PDB file loaded into the applet) | |
| - | + | or the SCENE parameter (which sets the initial scene displayed when the page is loaded), | |
| - | | | + | or leave the SCENE parameter empty for the default display. |
| - | | | + | --> |
| - | + | {{STRUCTURE_1bg7| PDB=1bg7 | SCENE= }} | |
| - | + | ||
| - | + | ||
| - | }} | + | |
'''LOCALIZED UNFOLDING AT THE JUNCTION OF THREE FERRITIN SUBUNITS. A MECHANISM FOR IRON RELEASE?''' | '''LOCALIZED UNFOLDING AT THE JUNCTION OF THREE FERRITIN SUBUNITS. A MECHANISM FOR IRON RELEASE?''' | ||
| Line 30: | Line 27: | ||
[[Category: Takagi, H.]] | [[Category: Takagi, H.]] | ||
[[Category: Theil, E C.]] | [[Category: Theil, E C.]] | ||
| - | [[Category: | + | [[Category: Ferritin]] |
| - | [[Category: | + | [[Category: Iron storage]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 11:28:24 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 08:28, 2 May 2008
LOCALIZED UNFOLDING AT THE JUNCTION OF THREE FERRITIN SUBUNITS. A MECHANISM FOR IRON RELEASE?
Overview
How and where iron exits from ferritin for cellular use is unknown. Twenty-four protein subunits create a cavity in ferritin where iron is concentrated >10(11)-fold as a mineral. Proline substitution for conserved leucine 134 (L134P) allowed normal assembly but increased iron exit rates. X-ray crystallography of H-L134P ferritin revealed localized unfolding at the 3-fold axis, also iron entry sites, consistent with shared use sites for iron exit and entry. The junction of three ferritin subunits appears to be a dynamic aperture with a "shutter" that cytoplasmic factors might open or close to regulate iron release in vivo.
About this Structure
1BG7 is a Single protein structure of sequence from Rana catesbeiana. Full crystallographic information is available from OCA.
Reference
Localized unfolding at the junction of three ferritin subunits. A mechanism for iron release?, Takagi H, Shi D, Ha Y, Allewell NM, Theil EC, J Biol Chem. 1998 Jul 24;273(30):18685-8. PMID:9668036 Page seeded by OCA on Fri May 2 11:28:24 2008
