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5ipo

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Revision as of 07:26, 3 June 2020

Solution Structure of Hge36: Scorpine-like Peptide from Hadrurus Gertschi

Structural highlights

5ipo is a 1 chain structure with sequence from Hofge. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[KBX3_HADGE] Hge-scorpine has antibacterial activity against B.subtilis, but not against S.aureus. Also has hemolytic and cytolytic activities.^[1] Hge36 peptide blocks Kv1.1/KCNA1 (IC(50)=185 nM) potassium channels. Shows a weak hemolytic activity.^[2]

Publication Abstract from PubMed

Scorpine-like peptides are two domain peptides found in different scorpion venoms displaying various antimicrobial, cytolytic, and potassium channel-blocking activities. The relative contribution of each domain to their different activities remains to be elucidated. Here, we report the recombinant production, solution structure, and antiparasitic activity of Hge36, first identified as a naturally occurring truncated form of a Scorpine-like peptide from the venom of Hoffmannihadrurus gertschi. We also show that removing the first four residues from Hge36 renders a molecule with enhanced potassium channel-blocking and antiparasitic activities. Our results are important to rationalize the structure-function relationships of a pharmacologically versatile molecular scaffold.

Solution structure and antiparasitic activity of scorpine-like peptides from Hoffmannihadrurus gertschi.,Flores-Solis D, Toledano Y, Rodriguez-Lima O, Cano-Sanchez P, Ramirez-Cordero BE, Landa A, Rodriguez de la Vega RC, Del Rio-Portilla F FEBS Lett. 2016 Jun 17. doi: 10.1002/1873-3468.12255. PMID:27314815^[3]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Diego-Garcia E, Abdel-Mottaleb Y, Schwartz EF, de la Vega RC, Tytgat J, Possani LD. Cytolytic and K+ channel blocking activities of beta-KTx and scorpine-like peptides purified from scorpion venoms. Cell Mol Life Sci. 2008 Jan;65(1):187-200. PMID:18030427 doi:http://dx.doi.org/10.1007/s00018-007-7370-x
↑ Diego-Garcia E, Abdel-Mottaleb Y, Schwartz EF, de la Vega RC, Tytgat J, Possani LD. Cytolytic and K+ channel blocking activities of beta-KTx and scorpine-like peptides purified from scorpion venoms. Cell Mol Life Sci. 2008 Jan;65(1):187-200. PMID:18030427 doi:http://dx.doi.org/10.1007/s00018-007-7370-x
↑ Flores-Solis D, Toledano Y, Rodriguez-Lima O, Cano-Sanchez P, Ramirez-Cordero BE, Landa A, Rodriguez de la Vega RC, Del Rio-Portilla F. Solution structure and antiparasitic activity of scorpine-like peptides from Hoffmannihadrurus gertschi. FEBS Lett. 2016 Jun 17. doi: 10.1002/1873-3468.12255. PMID:27314815 doi:http://dx.doi.org/10.1002/1873-3468.12255

1 Structural highlights
2 Function
3 Publication Abstract from PubMed
4 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/5ipo"

@@ Line 1: / Line 1: @@
 ==Solution Structure of Hge36: Scorpine-like Peptide from Hadrurus Gertschi==
-<StructureSection load='5ipo' size='340' side='right' caption='[[5ipo]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
+<StructureSection load='5ipo' size='340' side='right'caption='[[5ipo]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[5ipo]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IPO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5IPO FirstGlance]. <br>
+<table><tr><td colspan='2'>[[5ipo]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Hofge Hofge]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IPO OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5IPO FirstGlance]. <br>
-</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ipo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ipo OCA], [http://pdbe.org/5ipo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ipo RCSB], [http://www.ebi.ac.uk/pdbsum/5ipo PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ipo ProSAT]</span></td></tr>
+</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5ipo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ipo OCA], [http://pdbe.org/5ipo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ipo RCSB], [http://www.ebi.ac.uk/pdbsum/5ipo PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ipo ProSAT]</span></td></tr>
 </table>
 == Function ==
@@ Line 21: / Line 21: @@
 __TOC__
 </StructureSection>
+[[Category: Hofge]]
+[[Category: Large Structures]]
 [[Category: Flores-Solis, D]]
 [[Category: Rio-Portilla, F del]]

5ipo

From Proteopedia

Revision as of 07:26, 3 June 2020

Solution Structure of Hge36: Scorpine-like Peptide from Hadrurus Gertschi

Structural highlights

Function

Publication Abstract from PubMed

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

Views

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