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5iv4

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==Crystal structure of the human soluble cyclase in complex with the allosteric inhibitor LRE1==
==Crystal structure of the human soluble cyclase in complex with the allosteric inhibitor LRE1==
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<StructureSection load='5iv4' size='340' side='right' caption='[[5iv4]], [[Resolution|resolution]] 1.79&Aring;' scene=''>
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<StructureSection load='5iv4' size='340' side='right'caption='[[5iv4]], [[Resolution|resolution]] 1.79&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5iv4]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IV4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5IV4 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5iv4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IV4 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5IV4 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=LRI:6-CHLORO-N~4~-CYCLOPROPYL-N~4~-[(THIOPHEN-2-YL)METHYL]PYRIMIDINE-2,4-DIAMINE'>LRI</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=LRI:6-CHLORO-N~4~-CYCLOPROPYL-N~4~-[(THIOPHEN-2-YL)METHYL]PYRIMIDINE-2,4-DIAMINE'>LRI</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CME:S,S-(2-HYDROXYETHYL)THIOCYSTEINE'>CME</scene></td></tr>
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CME:S,S-(2-HYDROXYETHYL)THIOCYSTEINE'>CME</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ADCY10, SAC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Adenylate_cyclase Adenylate cyclase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.6.1.1 4.6.1.1] </span></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Adenylate_cyclase Adenylate cyclase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.6.1.1 4.6.1.1] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5iv4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5iv4 OCA], [http://pdbe.org/5iv4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5iv4 RCSB], [http://www.ebi.ac.uk/pdbsum/5iv4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5iv4 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5iv4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5iv4 OCA], [http://pdbe.org/5iv4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5iv4 RCSB], [http://www.ebi.ac.uk/pdbsum/5iv4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5iv4 ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
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</div>
</div>
<div class="pdbe-citations 5iv4" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5iv4" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[3D Adenylyl cyclase 3D structures|3D Adenylyl cyclase 3D structures]]
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Adenylate cyclase]]
[[Category: Adenylate cyclase]]
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[[Category: Human]]
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[[Category: Large Structures]]
[[Category: Kleinboelting, S]]
[[Category: Kleinboelting, S]]
[[Category: Steegborn, C]]
[[Category: Steegborn, C]]
[[Category: Human soluble adenylyl cyclase complex lre1 inhibitor]]
[[Category: Human soluble adenylyl cyclase complex lre1 inhibitor]]
[[Category: Lyase]]
[[Category: Lyase]]

Revision as of 07:32, 3 June 2020

Crystal structure of the human soluble cyclase in complex with the allosteric inhibitor LRE1

PDB ID 5iv4

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