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1bhd

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[[Image:1bhd.gif|left|200px]]
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{{Structure
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|GENE= UTRN, DMDL ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1bhd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bhd OCA], [http://www.ebi.ac.uk/pdbsum/1bhd PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1bhd RCSB]</span>
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'''SECOND CALPONIN HOMOLOGY DOMAIN FROM UTROPHIN'''
'''SECOND CALPONIN HOMOLOGY DOMAIN FROM UTROPHIN'''
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[[Category: Kendrick-Jones, J.]]
[[Category: Kendrick-Jones, J.]]
[[Category: Winder, S J.]]
[[Category: Winder, S J.]]
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[[Category: actin binding]]
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[[Category: Actin binding]]
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[[Category: calponin homology]]
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[[Category: Calponin homology]]
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[[Category: structural protein]]
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[[Category: Structural protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 11:30:57 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 19:01:00 2008''
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Revision as of 08:30, 2 May 2008

Image:1bhd.gif

Template:STRUCTURE 1bhd

SECOND CALPONIN HOMOLOGY DOMAIN FROM UTROPHIN


Overview

Utrophin is a close homologue of dystrophin, the protein defective in Duchenne muscular dystrophy. Like dystrophin, it is composed of three regions: an N-terminal region that binds actin filaments, a large central region with triple coiled-coil repeats, and a C-terminal region that interacts with components in the dystroglycan protein complex at the plasma membrane. The N-terminal actin-binding region consists of two calponin homology domains and is related to the actin-binding domains of a superfamily of proteins including alpha-actinin, spectrin and fimbrin. Here, we present the 2.0 A structure of the second calponin homology domain of utrophin solved by X-ray crystallography, and compare it to the other calponin homology domains previously determined from spectrin and fimbrin.

About this Structure

1BHD is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

The 2.0 A structure of the second calponin homology domain from the actin-binding region of the dystrophin homologue utrophin., Keep NH, Norwood FL, Moores CA, Winder SJ, Kendrick-Jones J, J Mol Biol. 1999 Jan 22;285(3):1257-64. PMID:9887274 Page seeded by OCA on Fri May 2 11:30:57 2008

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